从中国黑龙江省分离出的一种汉坦病毒的基因特征分析。
Genetic characterization of a hantavirus isolated from Heilongjiang province, China.
作者信息
Wang Yulong, Cao Suya, Cheng Cheng, Ju Wendong, Hua Yuping
机构信息
Northeast Forestry University, 26 Hexing Road, Harbin, 150040, China (Wang, Cao, Hua); Heilongjiang International Travel Healthcare Center, Harbin, 150000, China (Cheng, Ju).
出版信息
Can J Vet Res. 2019 Jan;83(1):75-77.
Hantavirus is the causative agent of hemorrhagic fever with renal syndrome (HFRS). Heilongjiang Province is experiencing an epidemic of HFRS, the main causative agent is a variant of hantavirus called Seoul virus (SEOV). In this study, the entire genome of one SEOV, the DN2 strain, was sequenced and analyzed. The alignment analysis of the sequences indicated that the DN2 strain shares the highest homology with the SEOV-LYO852 strain. The nucleotide identity is 97.6% for the S segment, 97.7% for the M segment, and 98.0% for the L segment. The corresponding amino acid sequence homologies are 99.1%, 98.9% and 99.8%. The phylogenetic analysis of the segments suggests that the DN2 strain has a high genetic relationship with SEOV strains and no genetic recombination occurs.
汉坦病毒是肾综合征出血热（HFRS）的病原体。黑龙江省正在经历肾综合征出血热疫情，主要病原体是一种名为汉城病毒（SEOV）的汉坦病毒变种。在本研究中，对一株SEOV（DN2株）的全基因组进行了测序和分析。序列比对分析表明，DN2株与SEOV-LYO852株具有最高的同源性。S片段的核苷酸同一性为97.6%，M片段为97.7%，L片段为98.0%。相应的氨基酸序列同源性分别为99.1%、98.9%和99.8%。各片段的系统发育分析表明，DN2株与SEOV株具有高度的遗传关系，未发生基因重组。
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