Yanxiao Gao, Mei Tian, Gang Gao, Xiaochun Wang, Jianxiang Liu
Key Laboratory of Radiological Protection and Nuclear Emergency, Department of Radiation Epidemiology, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, China.
Beijing Institute of Occupational Disease Prevention and Treatment, Beijing, China.
Dose Response. 2019 Jan 7;17(1):1559325818820974. doi: 10.1177/1559325818820974. eCollection 2019 Jan-Mar.
This study explored the effects of long-term bathing in radon hot springs on oxidative damage and antioxidation function in humans. In this study, blood was collected from residents in the Pingshan radon hot spring area (RHSA), Jiangzha RHSA, and control area (CA). 8-Hydroxydeoxyguanosine (8-OHdG) and thioredoxin reductase (TrxR), representing oxidation and antioxidant levels, respectively, were analyzed as indices. Compared to the CA group, the RHSA group in the Pingshan and Jiangzha areas showed significantly decreased 8-OHdG levels ( = -3.350, -3.316, respectively, < .05) and increased TrxR levels ( = 2.394, 3.773, respectively, < .05). The RHSA and CA groups in Jiangzha had lower levels of TrxR and 8-OHdG compared to those in Pingshan. This finding may be related to the different radon concentration levels, bathing time and other factors. Results suggested that long-term bathing in radon hot spring may activate antioxidant function and reduce oxidative damage in the body.
本研究探讨了长期泡氡温泉对人体氧化损伤和抗氧化功能的影响。在本研究中，采集了平山氡温泉区（RHSA）、江扎RHSA和对照区（CA）居民的血液。分别以代表氧化水平和抗氧化水平的8-羟基脱氧鸟苷（8-OHdG）和硫氧还蛋白还原酶（TrxR）作为指标进行分析。与CA组相比，平山和江扎地区的RHSA组8-OHdG水平显著降低（分别为=-3.350、-3.316，<.05），TrxR水平升高（分别为=2.394、3.773，<.05）。与平山地区相比，江扎地区的RHSA组和CA组TrxR和8-OHdG水平较低。这一发现可能与氡浓度水平、泡浴时间等因素不同有关。结果表明，长期泡氡温泉可能激活机体抗氧化功能并减少氧化损伤。
