Qureshi M Saeed, Alsughayyir Jawaher, Chhabra Manu, Ali Jason M, Goddard Martin J, Devine Chris, Conlon Thomas M, Linterman Michelle A, Motallebzadeh Reza, Pettigrew Gavin J
University of Cambridge, School of Clinical Medicine, Cambridge CB2 0QQ, UK.
Department of Pathology, Papworth Hospital, Papworth Everard, CB23 3RE, UK.
Data Brief. 2018 Dec 28;22:647-657. doi: 10.1016/j.dib.2018.12.078. eCollection 2019 Feb.
This data is related to the research article entitled "Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy" (Harper et al., 2016) [2]. The data presented here focuses on the humoral autoimmune response triggered by transferred allogeneic CD4 T cells and includes details on: (a) the recipient splenic germinal center (GC) response; (b) augmentation of humoral autoimmunity and accelerated heart allograft rejection following transplantation from donors primed against recipient; (c) flow cytometric analysis of donor and recipient CD4 T cells for signature markers of T follicular helper cell differentiation; (d) donor endothelial cell migration in response to column purified autoantibody from recipient sera; (e) analysis of development of humoral responses in recipients following adoptive transfer of donor CD4 T cells and; (f) the development of humoral autoimmunity in mixed haematopoietic chimeric mice.
这些数据与题为《生发中心体液自身免疫独立介导移植血管病变进展》的研究文章相关（Harper等人，2016年）[2]。此处呈现的数据聚焦于由转移的同种异体CD4 T细胞引发的体液自身免疫反应，包括以下细节：(a) 受体脾脏生发中心（GC）反应；(b) 来自针对受体进行预处理的供体的移植后，体液自身免疫增强和心脏同种异体移植排斥加速；(c) 对供体和受体CD4 T细胞进行流式细胞术分析，以检测T滤泡辅助细胞分化的特征性标志物；(d) 供体内皮细胞对来自受体血清的柱纯化自身抗体的迁移反应；(e) 受体在接受供体CD4 T细胞过继转移后体液反应的发展情况；以及(f) 混合造血嵌合小鼠中体液自身免疫的发展情况。
