Blakemore K J
Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Obstet Gynecol Clin North Am. 1988 Jun;15(2):179-213.
The future of chorionic villus sampling can only be envisioned in the light of current knowledge. Amniocentesis will undoubtedly continue to hold an important place in prenatal diagnosis and has recently assumed greater importance in diagnosing neural tube defects and Down syndrome through widespread maternal serum alpha-fetoprotein screening. Patients now have a choice in prenatal diagnostic procedures for most genetic disorders. Many are already choosing chorionic villus sampling despite the questions that remain regarding risks and diagnostic accuracy. Risk figures for miscarriages due to the procedure and for intrauterine infection are especially needed. The issues of maternal contamination in laboratory analyses and chromosomal mosaicism that may not be present in the fetus are also of prime importance. Collaborative efforts continue to answer these and other questions so that in the future patients will be better able to make informed decisions regarding prenatal diagnosis.
绒毛取样的未来只能根据目前的知识来设想。羊膜穿刺术无疑将继续在产前诊断中占据重要地位，并且最近通过广泛的母体血清甲胎蛋白筛查，在诊断神经管缺陷和唐氏综合征方面发挥了更大的作用。对于大多数遗传性疾病，患者现在在产前诊断程序上有了选择。尽管关于风险和诊断准确性仍存在问题，但许多人已经选择了绒毛取样。尤其需要因该操作导致流产和宫内感染的风险数据。实验室分析中的母体污染问题以及胎儿可能不存在的染色体镶嵌现象也至关重要。合作努力仍在继续，以回答这些及其他问题，以便未来患者能够更好地就产前诊断做出明智的决定。
