Goldberg J D, Porter A E, Golbus M S
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 94143.
Am J Med Genet. 1990 Feb;35(2):174-7. doi: 10.1002/ajmg.1320350206.
Chorionic villus sampling has been developed as a method of first trimester prenatal diagnosis. In order to evaluate this new approach, accurate risk figures for the procedure must be obtained. This has been difficult for a number of reasons, including establishment of baseline fetal loss rates in the first trimester, procedural "learning curves," and reporting biases. This review will discuss these problems and use data from the chorionic villus sampling program at the University of California, San Francisco, to illustrate difficulties in data interpretation.
绒毛取样已发展成为一种孕早期产前诊断的方法。为了评估这种新方法，必须获得该程序准确的风险数据。由于多种原因，这一直很困难，包括确定孕早期的基线胎儿丢失率、操作“学习曲线”以及报告偏差。本综述将讨论这些问题，并使用加利福尼亚大学旧金山分校绒毛取样项目的数据来说明数据解读中的困难。
