认知正常成年人的终生体力活动与脑白质高信号
Lifetime Physical Activity and White Matter Hyperintensities in Cognitively Intact Adults.
机构信息
Elisa R. Torres, PhD, RN, is Professor, University of Mississippi Medical Center School of Nursing, Jackson. At the time this data was collected, she was Associate Faculty, University of Iowa College of Nursing. Siobhan M. Hoscheidt, PhD, is Assistant Professor, Wake Forest School of Medicine, Winston-Salem, North Carolina. Barbara B. Bendlin, PhD, is Associate Professor, University of Wisconsin-Madison School of Medicine and Public Health. Vincent A. Magnotta, PhD, is Professor, University of Iowa College of Medicine. Gabriel D. Lancaster, MS, is Medical Student, University of Iowa College of Medicine. Roger L. Brown, PhD, is Professor, University of Wisconsin-Madison School of Nursing. Sergio Paradiso, MD, PhD, is Physician in Private Practice specializing in Psychiatry and Pyschotherapy, Catania, Italy.
出版信息
Nurs Res. 2019 May/Jun;68(3):210-217. doi: 10.1097/NNR.0000000000000341.
BACKGROUND
White matter hyperintensities (WMHs) observed on magnetic resonance images are associated with depression and increase the risk of stroke, dementia, and death. The association between physical activity and WMHs has been inconsistently reported in the literature, perhaps because studies did not account for a lifetime of physical activity or depression.
OBJECTIVES
The aim of this study was to determine the extent to which a lifetime of leisure-time physical activity is associated with less WMHs while accounting for depression.
METHODS
Face-to-face interviews were conducted with the Lifetime Total Physical Activity Questionnaire, where the metabolic equivalent of task hours per week per year was calculated. Cognitively intact participants also underwent magnetic resonance imaging, where WMHs as a percentage of intracranial volume was obtained. Hierarchical multiple linear regression was performed to compare WMHs in a more active group with a group with no psychiatric history (n = 20, mean age = 62.2 years), with a less active group with no psychiatric history (n = 13, mean age = 64.0 years), and a less active group with history of late-onset depression (n = 14, mean age = 62.8 years).
RESULTS
There was not a statistically significant difference in WMHlg10 between the more and less active groups without a psychiatric history (b = .09, p > .05) or between the more active group without a psychiatric history and the less active group with a history of depression (b = .01, p > .05). The model was predictive of WMHlg10, explaining an adjusted 15% of the variance in WMHs (p = .041).
DISCUSSION
A lifetime of leisure-time physical activity was not associated with WMHs when accounting for depression.
背景
磁共振图像上观察到的脑白质高信号（WMHs）与抑郁有关，并增加中风、痴呆和死亡的风险。在文献中，体力活动与 WMHs 之间的关联报道不一致，这可能是因为研究没有考虑到一生的体力活动或抑郁情况。
目的
本研究旨在确定在考虑抑郁的情况下，一生的休闲时间体力活动与较少的 WMHs 相关的程度。
方法
通过面对面访谈进行了生活方式总体力活动问卷，计算出每年每周每代谢当量的小时数。认知正常的参与者还接受了磁共振成像，获得了颅内容积百分比的 WMHs。采用分层多重线性回归比较无精神病史的更活跃组（n = 20，平均年龄为 62.2 岁）与无精神病史的较少活跃组（n = 13，平均年龄为 64.0 岁）以及有迟发性抑郁症病史的较少活跃组（n = 14，平均年龄为 62.8 岁）之间的 WMHs。
结果
无精神病史的更活跃组与较少活跃组之间的 WMHlg10 差异无统计学意义（b =.09，p >.05），或者无精神病史的更活跃组与有抑郁症病史的较少活跃组之间的 WMHlg10 差异也无统计学意义（b =.01，p >.05）。该模型对 WMHlg10 具有预测性，解释了 WMHs 变异的 15%（p =.041）。
讨论
在考虑抑郁的情况下，一生的休闲时间体力活动与 WMHs 无关。
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