薏仁麸油抑制2型糖尿病大鼠的肝脏糖异生并减轻高脂血症。

Adlay Bran Oil Suppresses Hepatic Gluconeogenesis and Attenuates Hyperlipidemia in Type 2 Diabetes Rats.

作者信息

Tseng Yi-Han, Chang Ching-Wen, Chiang Wenchang, Hsieh Shu-Chen

机构信息

Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.

出版信息

J Med Food. 2019 Jan;22(1):22-28. doi: 10.1089/jmf.2018.4237.

DOI:10.1089/jmf.2018.4237

PMID:30673500

Abstract

This study aimed to examine the antidiabetic effects of various concentrations of adlay bran oil (ABO) in high fat diet and streptozotocin-induced diabetic rats. Dietary supplementation with 10% ABO for 4 weeks effectively decreased the blood triacylglycerol, glucose, and total cholesterol levels in diabetic rats, although body weight remained the same. The mRNA and protein expressions of hepatic glucose transporter 2 (GLUT-2) and phosphoenolpyruvate carboxykinase (PEPCK) were increased and that of glucokinase (GCK) were decreased in diabetic rats. However, 10% ABO treatment reduced the mRNA and protein expressions of GLUT-2 and PEPCK and elevated the expression of hepatic GCK in diabetic rats. Thus, ABO enhanced hepatic glucose metabolism to decrease blood glucose in diabetic rats. In addition, 10% ABO supplementation increased the expression of phosphorylated protein kinase B (Akt) relative to the total Akt levels in the muscles of diabetic rats, indicating enhanced insulin sensitivity. The results indicate that ABO displays a potential for improving hyperlipidemia and hyperglycemia in diabetes by enhancing insulin sensitivity and hepatic glucose metabolism.

摘要

本研究旨在探讨不同浓度的薏苡麸皮油（ABO）对高脂饮食和链脲佐菌素诱导的糖尿病大鼠的抗糖尿病作用。尽管体重保持不变，但在糖尿病大鼠中，补充10%的ABO饮食4周可有效降低其血液中的三酰甘油、葡萄糖和总胆固醇水平。糖尿病大鼠肝脏葡萄糖转运蛋白2（GLUT-2）和磷酸烯醇式丙酮酸羧激酶（PEPCK）的mRNA和蛋白表达增加，而葡萄糖激酶（GCK）的表达降低。然而，10%的ABO处理降低了糖尿病大鼠肝脏中GLUT-2和PEPCK的mRNA和蛋白表达，并提高了肝脏GCK的表达。因此，ABO增强了糖尿病大鼠肝脏的葡萄糖代谢以降低血糖。此外，相对于糖尿病大鼠肌肉中总的蛋白激酶B（Akt）水平，补充10%的ABO增加了磷酸化Akt的表达，表明胰岛素敏感性增强。结果表明，ABO通过增强胰岛素敏感性和肝脏葡萄糖代谢，具有改善糖尿病患者高脂血症和高血糖的潜力。