Graduate Program of Nutrition Science, National Taiwan Normal University, Taipei 106308, Taiwan.
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Nutrients. 2021 Jul 4;13(7):2305. doi: 10.3390/nu13072305.
High blood pressure is a crucial risk factor for many cardiovascular diseases, and a diet rich in whole-grain foods may modulate blood pressure. This study investigated the effects of dehulled adlay consumption on blood pressure in vivo. We initially fed spontaneous hypertensive rats diets without (SHR group) or with 12 or 24% dehulled adlay (SHR + LA and SHR + HA groups), and discovered that it could limit blood pressure increases over a 12-week experimental period. Although we found no significant changes in plasma, heart, and kidney angiotensin-converting enzyme activities, both adlay-consuming groups had lower endothelin-1 and creatinine concentrations than the SHR group; the SHR + HA group also had lower aspartate aminotransferase and uric acid levels than the SHR group did. We later recruited 23 participants with overweight and obesity, and they consumed 60 g of dehulled adlay daily for a six-week experimental period. At the end of the study, we observed a significant decrease in the group's systolic blood pressure (SBP), and the change in SBP was even more evident in participants with high baseline SBP. In conclusion, our results suggested that daily intake of dehulled adlay had beneficial effects in blood-pressure management. Future studies may further clarify the possible underlying mechanisms for the consuming of dehulled adlay as a beneficial dietary approach for people at risk of hypertension.
高血压是许多心血管疾病的关键危险因素，而富含全谷物的饮食可能可以调节血压。本研究旨在探讨去壳薏苡摄入对体内血压的影响。我们最初给自发性高血压大鼠喂食不含（SHR 组）或含 12%或 24%去壳薏苡（SHR+LA 和 SHR+HA 组）的饮食，发现它可以在 12 周的实验期间限制血压升高。尽管我们没有发现血浆、心脏和肾脏血管紧张素转换酶活性有显著变化，但两个食用薏苡组的内皮素-1和肌酐浓度均低于 SHR 组；SHR+HA 组的天冬氨酸转氨酶和尿酸水平也低于 SHR 组。后来，我们招募了 23 名超重和肥胖的参与者，让他们在六周的实验期间每天食用 60 克去壳薏苡。研究结束时，我们观察到该组的收缩压（SBP）显著下降，而基线 SBP 较高的参与者的 SBP 变化更为明显。总之，我们的研究结果表明，每天摄入去壳薏苡对血压管理有有益的影响。未来的研究可能会进一步阐明食用去壳薏苡作为高血压高危人群有益饮食方法的潜在机制。
