Martsievich S Iu, Metelitsa V I
Ter Arkh. 1988;60(8):27-30.
The action of various dosage forms of isosorbide dinitrate (ID) was studied with the help of repeated treadmill run in 28 CHD patients with stable angina of effort. The mean duration of the antianginal effect of ID standard tablets (nitrosorbide-NS) at a dose of 10 mg per os was 3.0 +/- 0.4 h. The effect of sublingual NS administration was more marked and the duration slightly less than in NS administration per os. ID of prolonged action isomac-retard containing 40 mg of ID produced an effect, insignificantly exceeding in duration the NS effect. Dinitrosorbilong (DNL) for gingival application produced and effect as marked as that of sublingual NS. The duration of the DNL effect significantly exceeded that of the effect of all ID dosage form under study (over 8 h). An increase in a NS dose per os did not result in an effect of the same degree and duration as that of DNL.
在28例稳定型劳力性心绞痛冠心病患者中，借助重复平板运动试验研究了硝酸异山梨酯（ID）各种剂型的作用。口服10mg剂量的ID标准片（硝异山梨酯-NS）抗心绞痛作用的平均持续时间为3.0±0.4小时。舌下含服NS的效果更明显，持续时间略短于口服NS。含40mg ID的长效异舒吉缓释片产生的作用，其持续时间仅略长于NS的作用。用于牙龈给药的二硝异山梨酯（DNL）产生的作用与舌下含服NS的作用一样显著。DNL作用的持续时间显著超过所研究的所有ID剂型的作用持续时间（超过8小时）。口服NS剂量增加并未产生与DNL相同程度和持续时间的作用。
