Department of Stomatology, Tongji Hospital of Tongji Medical College of Huazhong, University of Science and Technology, Wuhan, China.
Centers for Disease Control and Prevention of Wuhan, Wuhan, China.
Oral Dis. 2020 Mar;26(2):259-269. doi: 10.1111/odi.13045. Epub 2019 Feb 11.
Periodontal disease is a chronic inflammatory disease leading to destruction of periodontal tissues. As a local inflammation, periodontopathic bacterium, pro-inflammatory mediators, and local immune response play pivotal role in the progress of periodontal disease. Besides, cigarette smoke has long been associated with periodontal disease and tooth loss. Autophagy is an intracellular degradation process highly conserved from yeast to humans. As a lysosomal degradation pathway of self-digestion, it is critical for maintaining cells homeostasis and development. The role of autophagy has been investigated in oral diseases, such as oral cancer, periapical lesions, and oral candidiasis. Recently, increasing studies investigated the role of autophagy in periodontal disease. In this review, we try to illustrate the effect of autophagy on periodontal disease pathogenesis from 5 aspects: autophagy affects the intracellular infection and survival of bacteria; autophagy has an interaction with periodontal inflammation; autophagy is pivotal in periodontal cells biology and periodontal tissues destruction and reconstruction; autophagy can be induced by cigarette smoke; last but not least, autophagy may affect periodontal disease via endoplasmic reticulum stress.
牙周病是一种慢性炎症性疾病，导致牙周组织破坏。作为一种局部炎症，牙周病致病菌、促炎介质和局部免疫反应在牙周病的进展中起着关键作用。此外，吸烟与牙周病和牙齿缺失长期相关。自噬是一种从酵母到人高度保守的细胞内降解过程。作为一种溶酶体降解途径的自我消化，它对维持细胞内环境平衡和发育至关重要。自噬在口腔疾病中的作用，如口腔癌、根尖病变和口腔念珠菌病，已经得到了广泛的研究。最近，越来越多的研究探讨了自噬在牙周病中的作用。在这篇综述中，我们试图从 5 个方面阐述自噬对牙周病发病机制的影响：自噬影响细菌的细胞内感染和存活；自噬与牙周炎症相互作用；自噬在牙周细胞生物学和牙周组织破坏与重建中起关键作用；自噬可被香烟烟雾诱导；最后但同样重要的是，自噬可能通过内质网应激影响牙周病。
