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韩国成人肺移植病例数量及住院和长期死亡率

Adult lung transplantation case-volume and in-hospital and long-term mortality in Korea.

作者信息

Yoon Susie, Jang Eun Jin, Kim Ga Hee, Kim Dal Ho, Lim Tae-Yoon, Lee Hannah, Ryu Ho Geol

机构信息

Department of Anaesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Department of Information Statistics, Andong National University, 1375 Gyeongdong-ro, Andong-si, Gyeongsangbuk-do, 36729, South Korea.

出版信息

J Cardiothorac Surg. 2019 Jan 23;14(1):19. doi: 10.1186/s13019-019-0849-3.

Abstract

BACKGROUND

The inverse relationship between case-volume and surgical mortality has been reported in complex surgical procedures. The aim of this study was to evaluate the effect of case-volume on mortality after lung transplantation in Korea.

METHODS

The National Health Insurance Service data was used to analyse all adult lung transplantations in Korea between 2007 and 2016. Institutions were categorized into low-volume (< 5 lung transplantations/year) centers or high-volume (≥ 5 lung transplantations/year) centers. Risk-adjusted in-hospital mortality and long-term survival according to case-volume was evaluated.

RESULTS

A total of 315 adult recipients underwent lung transplantation at 7 centers. The odds ratio for in-hospital mortality in low-volume centers was similar to high-volume centers (OR, 1.496; 95% CI, 0.81-2.76; p = 0.197). Log-rank analysis of Kaplan-Meier curves according to case-volume also did not show a difference in long-term survival between high- and low-volume centers (p = 0.052).

CONCLUSIONS

There was no association between case-volume and in-hospital mortality after lung transplantation in Korea, although there was a tendency towards better long-term survival associated with high-volume centers.

摘要

背景

在复杂外科手术中,病例数量与手术死亡率之间存在负相关关系已被报道。本研究的目的是评估病例数量对韩国肺移植术后死亡率的影响。

方法

利用国民健康保险服务数据,分析2007年至2016年韩国所有成人肺移植病例。机构被分为低病例量中心(每年<5例肺移植)或高病例量中心(每年≥5例肺移植)。评估根据病例数量调整风险后的住院死亡率和长期生存率。

结果

共有315名成年受者在7个中心接受了肺移植。低病例量中心的住院死亡率优势比与高病例量中心相似(优势比,1.496;95%置信区间,0.81 - 2.76;p = 0.197)。根据病例数量对Kaplan-Meier曲线进行的对数秩分析也未显示高病例量中心和低病例量中心在长期生存率上存在差异(p = 0.052)。

结论

在韩国,肺移植术后病例数量与住院死亡率之间没有关联,尽管高病例量中心有长期生存率更好的趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a14/6343357/26a66682edb7/13019_2019_849_Fig1_HTML.jpg

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