Sun Tao, Li Xingfu, Shi Qing, Wang Huaping, Huang Qiang, Fukuda Toshio
Beijing Advanced Innovation Center for Intelligent Robots and Systems, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 10081, China.
Gels. 2018 Apr 23;4(2):38. doi: 10.3390/gels4020038.
Tissue engineering is focusing on processing tissue micro-structures for a variety of applications in cell biology and the "bottom-up" construction of artificial tissue. Over the last decade, microfluidic devices have provided novel tools for producing alginate hydrogel microfibers with various morphologies, structures, and compositions for cell cultivation. Moreover, microfluidic spun alginate microfibers are long, thin, and flexible, and these features facilitate higher-order assemblies for fabricating macroscopic cellular structures. In this paper, we present an overview of the microfluidic spinning principle of alginate hydrogel microfibers and their application as micro-scaffolds or scaffolding elements for 3D assembly in tissue engineering.
组织工程专注于处理组织微结构，以用于细胞生物学的各种应用以及人工组织的“自下而上”构建。在过去十年中，微流控装置为生产具有各种形态、结构和组成的藻酸盐 hydrogel 微纤维用于细胞培养提供了新颖的工具。此外，微流控纺丝的藻酸盐微纤维长、细且柔韧，这些特性有助于进行高阶组装以制造宏观细胞结构。在本文中，我们概述了藻酸盐 hydrogel 微纤维的微流控纺丝原理及其作为组织工程中三维组装的微支架或支架元件的应用。
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