School of Biomedical Engineering, College of Health Science, Korea University, Seoul, 02841, Republic of Korea.
KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Biomaterials. 2017 Jan;114:121-143. doi: 10.1016/j.biomaterials.2016.10.040. Epub 2016 Nov 5.
Micro- or nanofiber-based materials have extensive applications in biomedical fields due to their capability to mimic many aspects of physiological microenvironment in vivo. Fabricating micro- or nanofibers using biocompatible and biodegradable materials is becoming of great interest in the area of biomaterials and tissue engineering. Among the various technologies, electrospinning and microfluidic spinning are the two promising approaches to produce fibers at micro- and nano-scale. Choosing an appropriate spinning method is critical important for a specific application. Although some review papers on each spinning method have been published, a review comparing these two methods has not been reported yet. In this review, we present an overview of the two spinning methods including the spinning principle, their unique features and materials selections. Several applications of fibers spun by both methods, especially in tissue engineering, organ function regeneration and drug delivery are introduced. The current challenges, future directions and potential applications of these approaches are discussed as well.
基于微/纳米纤维的材料由于能够模拟体内生理微环境的许多方面，因此在生物医学领域有广泛的应用。使用生物相容性和可生物降解材料制造微/纳米纤维在生物材料和组织工程领域引起了极大的兴趣。在各种技术中，静电纺丝和微流控纺丝是在微/纳米尺度生产纤维的两种很有前途的方法。选择一种合适的纺丝方法对于特定的应用至关重要。尽管已经发表了一些关于每种纺丝方法的综述论文，但尚未有对这两种方法进行比较的综述。在这篇综述中，我们介绍了这两种纺丝方法，包括纺丝原理、它们的独特特点和材料选择。介绍了这两种方法纺出的纤维的一些应用，特别是在组织工程、器官功能再生和药物输送方面的应用。还讨论了这些方法的当前挑战、未来方向和潜在应用。
