慢性肾脏病的遗传和环境风险因素。
Genetic and environmental risk factors for chronic kidney disease.
作者信息
Obrador Gregorio T, Schultheiss Ulla T, Kretzler Matthias, Langham Robyn G, Nangaku Masaomi, Pecoits-Filho Roberto, Pollock Carol, Rossert Jerome, Correa-Rotter Ricardo, Stenvinkel Peter, Walker Robert, Yang Chih-Wei, Fox Caroline S, Köttgen Anna
机构信息
Department of Epidemiology, Biostatistics and Public Health, Universidad Panamericana School of Medicine, Mexico City, Mexico.
Institute of Genetic Epidemiology, Medical Center and Faculty of Medicine-University of Freiburg, Freiburg, Germany.
出版信息
Kidney Int Suppl (2011). 2017 Oct;7(2):88-106. doi: 10.1016/j.kisu.2017.07.004. Epub 2017 Sep 20.
In order to change the current state of chronic kidney disease knowledge and therapeutics, a fundamental improvement in the understanding of genetic and environmental causes of chronic kidney disease is essential. This article first provides an overview of the existing knowledge gaps in our understanding of the genetic and environmental causes of chronic kidney disease, as well as their interactions. The second part of the article formulates goals that should be achieved in order to close these gaps, along with suggested timelines and stakeholders that are to be involved. A better understanding of genetic and environmental factors and their interactions that influence kidney function in healthy and diseased conditions can provide novel insights into renal physiology and pathophysiology and result in the identification of novel therapeutic or preventive targets to tackle the global public health care problem of chronic kidney disease.
为了改变慢性肾脏病知识和治疗的现状，从根本上提高对慢性肾脏病遗传和环境病因的认识至关重要。本文首先概述了我们在理解慢性肾脏病遗传和环境病因及其相互作用方面现有的知识空白。文章的第二部分制定了为填补这些空白应实现的目标，以及建议的时间线和相关利益者。更好地理解在健康和患病状态下影响肾功能的遗传和环境因素及其相互作用，可为肾脏生理学和病理生理学提供新的见解，并有助于确定新的治疗或预防靶点，以解决慢性肾脏病这一全球公共卫生问题。
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