Julius Global Health/Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Pediatrics, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Am J Trop Med Hyg. 2019 Mar;100(3):630-634. doi: 10.4269/ajtmh.18-0672.
We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 µm (95% confidence interval [CI]: 10.0-75.3, = 0.01), and 61.7 µm (95% CI: 21.5-102.0, < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.
我们在资源有限的环境中评估了 28 名曾患有登革出血热（DHF）的儿童和青少年（DHF 与心血管评估之间的平均间隔为 8.4 年）以及 34 名对照者的颈动脉内膜中层厚度（cIMT）和动脉僵硬程度。在登革休克综合征亚组分析中，既往患有 DHF 的参与者的 cIMT 调整后增加了 42.6 µm（95%置信区间 [CI]：10.0-75.3， = 0.01）和 61.7 µm（95% CI：21.5-102.0，<0.01）。动脉僵硬程度没有差异。在这项首次探索性研究中，患有 DHF 的儿童和青少年的 cIMT 增加，其严重程度可能受到 DHF 的调节。
