曾患登革出血热的儿童颈动脉内膜中层厚度增加。
Increased Carotid Intima-Media Thickness in Children with a History of Dengue Hemorrhagic Fever.
机构信息
Julius Global Health/Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Pediatrics, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
出版信息
Am J Trop Med Hyg. 2019 Mar;100(3):630-634. doi: 10.4269/ajtmh.18-0672.
We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 µm (95% confidence interval [CI]: 10.0-75.3, = 0.01), and 61.7 µm (95% CI: 21.5-102.0, < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.
我们在资源有限的环境中评估了 28 名曾患有登革出血热（DHF）的儿童和青少年（DHF 与心血管评估之间的平均间隔为 8.4 年）以及 34 名对照者的颈动脉内膜中层厚度（cIMT）和动脉僵硬程度。在登革休克综合征亚组分析中，既往患有 DHF 的参与者的 cIMT 调整后增加了 42.6 µm（95%置信区间 [CI]：10.0-75.3， = 0.01）和 61.7 µm（95% CI：21.5-102.0，<0.01）。动脉僵硬程度没有差异。在这项首次探索性研究中，患有 DHF 的儿童和青少年的 cIMT 增加，其严重程度可能受到 DHF 的调节。
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