Feldman Steven R, Hur Peter, Zhao Yang, Tian Haijun, Wei Zhongyuan, Wang Xinyue, Herrera Vivian
Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.
Dermatol Online J. 2018 Oct 15;24(10):13030/qt2m18n6vj.
Psoriasis is associated with a substantial burden of comorbidities; however, incidence rates (IRs) of these comorbidities following psoriasis diagnosis are not well characterized. Using administrative claims data from the Truven Health Analytics MarketScan Commercial and Medicare Supplemental Databases between January 1, 2002 and September 30, 2015, we compared the incidence of newly diagnosed comorbidities among patients with psoriasis versus demographically matched (birth year, gender, and geographic region) control patients without psoriasis in the United States. Comorbidities of interest were identified using ICD-9-CM codes. A total of 114,824 matched pairs of patients with psoriasis and control patients were included. IRs of all selected comorbidities were significantly higher among patients with psoriasis compared with controls (P<0.05). The most common newly diagnosed comorbidities in both groups were hyperlipidemia (psoriasis versus control, IR per 1,000 patient-years, 127.5 versus 102.8) and hypertension (94.3 versus 80.6). The greatest differences in IRs between patients with psoriasis and controls were observed for rheumatoid arthritis (9.7 versus 3.1; IR ratio [IRR], 3.15) and psoriatic arthritis (24.0 versus 0.2; IRR, 151.57). In this real-world study, patients with psoriasis were more likely to develop new selected comorbidities after diagnosis compared with demographically matched patients without psoriasis.
银屑病与大量共病负担相关；然而，银屑病诊断后这些共病的发病率并未得到很好的描述。利用2002年1月1日至2015年9月30日期间Truven Health Analytics市场扫描商业数据库和医疗保险补充数据库中的管理索赔数据，我们比较了美国银屑病患者与人口统计学匹配（出生年份、性别和地理区域）的无银屑病对照患者中新诊断共病的发病率。使用ICD-9-CM编码确定感兴趣的共病。总共纳入了114,824对银屑病患者和对照患者。与对照组相比，银屑病患者中所有选定共病的发病率均显著更高（P<0.05）。两组中最常见的新诊断共病是高脂血症（银屑病组与对照组，每1000患者年发病率，127.5对102.8）和高血压（94.3对80.6）。银屑病患者和对照组之间发病率差异最大的是类风湿性关节炎（9.7对3.1；发病率比[IRR]，3.15）和银屑病关节炎（24.0对0.2；IRR，151.57）。在这项真实世界研究中，与人口统计学匹配的无银屑病患者相比，银屑病患者在诊断后更有可能发生新的选定共病。
