Bhat Meghashyam, Bhat Sreevidya, Roberts-Thomson Kaye, Do Loc Giang
Department of Public Health Dentistry, Sharavathi Dental College and Hospital, Shimoga, India. Email:
Asian Pac J Cancer Prev. 2019 Jan 25;20(10):283-287. doi: 10.31557/APJCP.2019.20.1.283.
Objective: To examine if periodontitis is independently associated with oral potentially malignant disorders (OPMD) in a rural Indian adult population aged 35-54 years. Methods: A population-based cross-sectional study was conducted in rural India from 2011 to 2012. Multistage stratified cluster random sampling was followed to recruit 1401 participants aged 35-54 years. Face-to-face interviews were conducted to collect data on sociodemographic factors, tobacco and alcohol use. Oral examinations were done to record OPMD, periodontal findings and missing teeth. Univariate, bivariate and multivariable analyses were achieved using SPSS version 16 Chicago, SPSS Inc. OPMDs (leukoplakia, erythroplakia, oral submucous fibrosis (OSF) and suspicious malignant lesion) whether present or absent were selected as outcome variables; age, sex, socioeconomic factors, smoking, tobacco-chewing status, alcohol use, and periodontitis were considered as the predictor variables. Results: Among 873 participants, 44 demonstrated 47 lesions. Leukoplakia (n=21), erythroplakia (n=3), OSF (n=21), and suspicious malignant lesions (n=2) were present, strongly associated with past tobacco-chewing status [OR=9.22 (2.57-33.15)], current tobacco-chewing status [OR=15.49 (6.20-38.74)] and moderate/severe periodontitis [OR=3.19 (1.11-9.12)]. Conclusion: Periodontitis is a risk indicator for OPMD, independent of socioeconomic factors and tobacco-chewing. Tobacco-chewing status, both past and current, was strongly associated with OPMD in our rural Indian population.
探讨在年龄为35 - 54岁的印度农村成年人群中，牙周炎是否与口腔潜在恶性疾病（OPMD）独立相关。方法：2011年至2012年在印度农村地区开展了一项基于人群的横断面研究。采用多阶段分层整群随机抽样方法招募了1401名年龄在35 - 54岁的参与者。通过面对面访谈收集社会人口学因素、烟草和酒精使用情况的数据。进行口腔检查以记录OPMD、牙周检查结果和缺失牙情况。使用SPSS 16.0版软件（芝加哥，SPSS公司）进行单变量、双变量和多变量分析。将是否存在OPMD（白斑、红斑、口腔黏膜下纤维化（OSF）和可疑恶性病变）作为结局变量；将年龄、性别、社会经济因素、吸烟、嚼烟状况、酒精使用和牙周炎作为预测变量。结果：在873名参与者中，44人有47处病变。存在白斑（n = 21）、红斑（n = 3）、OSF（n = 21）和可疑恶性病变（n = 2），这些病变与既往嚼烟状况[比值比（OR）= 9.22（2.57 - 33.15）]、当前嚼烟状况[OR = 15.49（6.20 - 38.74）]以及中度/重度牙周炎[OR = 3.19（1.11 - 9.12）]密切相关。结论：牙周炎是OPMD的一个风险指标，独立于社会经济因素和嚼烟情况。在我们的印度农村人群中，既往和当前的嚼烟状况均与OPMD密切相关。
