一名围产期感染 HIV 的儿童，在停止抗逆转录病毒治疗后长期持续病毒学控制。
A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation.
机构信息
Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, PO Box 114, Diepkloof, Soweto, 1864, South Africa.
Family Clinical Research Unit, Department of Paediatrics and Child Health, Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa.
出版信息
Nat Commun. 2019 Jan 24;10(1):412. doi: 10.1038/s41467-019-08311-0.
Understanding HIV remission in rare individuals who initiated antiretroviral therapy (ART) soon after infection and then discontinued, may inform HIV cure interventions. Here we describe features of virus and host of a perinatally HIV-1 infected child with long-term sustained virological control. The child received early limited ART in the Children with HIV Early antiRetroviral therapy (CHER) trial. At age 9.5 years, diagnostic tests for HIV are negative and the child has characteristics similar to uninfected children that include a high CD4:CD8 ratio, low T cell activation and low CCR5 expression. Virus persistence (HIV-1 DNA and plasma RNA) is confirmed with sensitive methods, but replication-competent virus is not detected. The child has weak HIV-specific antibody and T cell responses. Furthermore, we determine his HLA and KIR genotypes. This case aids in understanding post-treatment control and may help design of future intervention strategies.
了解在感染后不久即开始接受抗逆转录病毒疗法（ART）并随后停止治疗的极少数个体中 HIV 缓解的情况，可能为 HIV 治愈干预措施提供信息。在此，我们描述了一位经母婴垂直传播感染 HIV-1 的儿童的病毒和宿主特征，该儿童在儿童期 HIV 早期抗逆转录病毒治疗（CHER）试验中接受了早期有限的 ART 治疗。在 9.5 岁时，HIV 诊断检测呈阴性，且该儿童具有与未感染者相似的特征，包括高 CD4:CD8 比值、低 T 细胞激活和低 CCR5 表达。使用敏感方法证实了病毒持续存在（HIV-1 DNA 和血浆 RNA），但未检测到复制有活性的病毒。该儿童具有较弱的 HIV 特异性抗体和 T 细胞反应。此外，我们还确定了他的 HLA 和 KIR 基因型。该病例有助于了解治疗后的控制情况，并可能有助于设计未来的干预策略。
Zotero 插件