Ag(I) 和 Au(III) 巯基苯并噻唑配合物诱导细胞凋亡死亡。
Ag(I) and Au(III) Mercaptobenzothiazole complexes induced apoptotic cell death.
机构信息
Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, India.
Cellular and Molecular Neurobiology Unit, Department of Biology, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, 342011, India.
出版信息
Sci Rep. 2019 Jan 24;9(1):621. doi: 10.1038/s41598-018-36801-6.
2-Mercaptobenzothiazole (MBT) complexes of Ag(I) and Au(III) were synthesized by wet chemical method. The structural, optical, HNMR, ICP - MS and electrochemical studies of the complexes were carried out. The TUNEL assay studies of Ag(I)MBT and Au(III)MBT complexes on A549 cell line indicated induced apoptosis in the cells. TUNEL assay showed 60% cell viability for Ag(I)MBT whereas 80% for Au(III)MBT. Thus Ag(I)MBT can induce cell apoptosis in cells at a higher rate than Au(III)MBT. Therefore these complexes studied here can be a viable option as anti - proliferating agent.
2-巯基苯并噻唑（MBT）的银（I）和金（III）配合物通过湿化学方法合成。对配合物进行了结构、光学、HNMR、ICP-MS 和电化学研究。Ag（I）MBT 和 Au（III）MBT 配合物对 A549 细胞系的 TUNEL 检测研究表明诱导了细胞凋亡。TUNEL 检测显示 Ag（I）MBT 的细胞活力为 60%，而 Au（III）MBT 的细胞活力为 80%。因此，Ag（I）MBT 可以比 Au（III）MBT 以更高的速率诱导细胞凋亡。因此，这里研究的这些配合物可以作为一种可行的抗增殖剂。
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