Payne S M
Department of Microbiology, University of Texas, Austin.
Crit Rev Microbiol. 1988;16(2):81-111. doi: 10.3109/10408418809104468.
The ability of bacterial pathogens to acquire iron in the host is an essential component of the disease process. Pathogenic Enterobacteriaceae spp. may either scavenge host iron sources such as heme or induce high-affinity iron-transport systems to remove iron from host proteins. The ease with which iron is acquired from the host will be at least partially determined by the iron status of the host at the time of infection. In response to infection, mammalian hosts reduce serum iron levels and withhold iron from the invading microorganisms. Thus the competition for iron is an active process which influences the outcome of a host-bacterial interaction.
细菌病原体在宿主体内获取铁的能力是疾病进程的一个重要组成部分。致病性肠杆菌科细菌可以清除宿主铁源，如血红素，或者诱导高亲和力的铁转运系统从宿主蛋白中去除铁。从宿主获取铁的难易程度至少部分取决于感染时宿主的铁状态。作为对感染的反应，哺乳动物宿主会降低血清铁水平，并阻止铁进入入侵的微生物。因此，对铁的竞争是一个活跃的过程，它影响着宿主与细菌相互作用的结果。
