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一名急性髓系白血病患儿的曲霉病:并发症及治疗

Aspergillosis in a Child with Acute Myeloid Leukemia: Complications, and Treatment.

作者信息

Horri Azadeh, Khademi Mehrnaz, Faryabi Javad, Shojaeepour Razieh

机构信息

Dept. of Pediatric Dentistry, Oral and Dental Research Center, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.

Dept. of Pediatric Dentistry, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran.

出版信息

J Dent (Shiraz). 2018 Dec;19(4):320-324.

PMID:30680306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6338690/
Abstract

Microbial infection is common in patients with leukemia. However, aspergillosis is a rare complication of oral region. Attention to early diagnosis and multidisciplinary treatment can reduce the wide range of complications of the infection in these patients. This article reports 4-year history of a child with leukemia, who suffered from a rare aspergillosis infection in the palatal region of oral cavity during chemotherapy. Early diagnosis and treatment of bacterial and fungal infections, especially rare types such as aspergillosis, in patients with leukemia is important for reducing widespread complications. However, prosthetic treatment and attention to psychological complications of orofacial defects would also improve their quality of life significantly. These improvements can be seen more clearly in children.

摘要

微生物感染在白血病患者中很常见。然而,曲霉病是口腔区域罕见的并发症。重视早期诊断和多学科治疗可以减少这些患者感染的广泛并发症。本文报告了一名白血病患儿的4年病史,该患儿在化疗期间口腔腭部区域遭受了罕见的曲霉病感染。对白血病患者的细菌和真菌感染,尤其是曲霉病等罕见类型进行早期诊断和治疗,对于减少广泛的并发症很重要。然而,修复治疗以及对口面部缺损心理并发症的关注也将显著改善他们的生活质量。这些改善在儿童中更为明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2732/6338690/1b3ccb846696/JDS-19-320-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2732/6338690/fc749fd466dd/JDS-19-320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2732/6338690/305f71b9d1d4/JDS-19-320-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2732/6338690/e3170fedcb12/JDS-19-320-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2732/6338690/1b3ccb846696/JDS-19-320-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2732/6338690/fc749fd466dd/JDS-19-320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2732/6338690/305f71b9d1d4/JDS-19-320-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2732/6338690/e3170fedcb12/JDS-19-320-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2732/6338690/1b3ccb846696/JDS-19-320-g004.jpg

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本文引用的文献

1
High Incidences of Invasive Fungal Infections in Acute Myeloid Leukemia Patients Receiving Induction Chemotherapy without Systemic Antifungal Prophylaxis: A Prospective Observational Study in Taiwan.在未接受全身性抗真菌预防的急性髓系白血病患者中,侵袭性真菌感染的高发生率:台湾的一项前瞻性观察研究。
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Infections increase the risk of central venous catheter-related thrombosis in adult acute myeloid leukemia.感染会增加成人急性髓系白血病中心静脉导管相关血栓形成的风险。
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Mycoses. 2013 Nov;56(6):687-9. doi: 10.1111/myc.12087. Epub 2013 May 15.
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Invasive oral aspergillosis in a patient with acute myeloid leukaemia.急性髓系白血病患者的侵袭性口腔曲霉病。
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Prophylactic antibiotics reduce morbidity due to septicemia during intensive treatment for pediatric acute myeloid leukemia.预防性抗生素可降低小儿急性髓系白血病强化治疗期间败血症所致的发病率。
Cancer. 2008 Jul 15;113(2):376-82. doi: 10.1002/cncr.23563.
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Pseudomembranous necrotizing tracheobronchitis caused by Aspergillus spp--contribution of one case with acute myeloid leukemia.曲霉属真菌引起的假膜性坏死性气管支气管炎——1例急性髓系白血病患者的病例报告
Folia Med (Plovdiv). 2006;48(3-4):93-7.
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Invasive pulmonary aspergillosis: role of early diagnosis and surgical treatment in patients with acute leukemia.侵袭性肺曲霉病:早期诊断及外科治疗在急性白血病患者中的作用
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