Guzek J W, Lewandowska A, Stempniak B
Department of Pathophysiology, University School of Medicine, Lódź, Poland.
Exp Clin Endocrinol. 1988 Sep;92(1):43-50. doi: 10.1055/s-0029-1210780.
No significant effect of intracerebroventricular administration of insulin on the bioassayed neurohypophysial storage of vasopressin and oxytocin could be found. This finding, however, only indirectly reflects possible changes of vasopressin and oxytocin release. Incubation of neurointermediate lobes in Locke's solution containing 3.3 mumol/l insulin resulted in an inhibition of oxytocin release under resting conditions as well as in a decrease of both vasopressin and oxytocin release during depolarization due to excess potassium. These results seem to suggest a possible regulatory role of brain insulin in the mechanisms of release of neurohypophysial hormones.
未发现脑室内注射胰岛素对生物测定的神经垂体中血管加压素和催产素的储存有显著影响。然而，这一发现仅间接反映了血管加压素和催产素释放可能发生的变化。将神经中间叶在含有3.3 μmol/l胰岛素的洛克溶液中孵育，导致在静息条件下催产素释放受到抑制，以及在因钾过量导致的去极化过程中血管加压素和催产素释放均减少。这些结果似乎表明脑胰岛素在神经垂体激素释放机制中可能具有调节作用。
