Department of Paediatric Rehabilitation, Princess Margaret Hospital, Perth, Western Australia, Australia.
University of Western Australia, Perth, Western Australia, Australia.
Muscle Nerve. 2019 May;59(5):590-593. doi: 10.1002/mus.26426. Epub 2019 Feb 14.
Currently, our knowledge of standard data for muscle morphology in children is largely limited to the 1969 article by Brooke and Engel (BE). In 2016, we reported normal muscle morphology from vastus lateralis biopsies in ambulant children with cerebral palsy (CP). This report compares our normal biopsy results against BE standard value criteria.
Single-blind prospective cross-sectional study design.
Results of biopsies taken in ambulant children with CP were normal according to morphometry and light and electron microscopy; however, only 5 of 10 fulfilled the BE standard value criteria.
This short report highlights the requirement for contemporary age-specific normative data from a larger number of biopsies, including typically developing children. Review of the literature suggests that biopsy material may be available from typically developing children who were control patients in research trials. This morphometric data could contribute to expanding the normative data set. Muscle Nerve 59:590-590, 2019.
目前，我们对于儿童肌肉形态学标准数据的了解主要局限于 Brooke 和 Engel（BE）于 1969 年发表的文章。2016 年，我们报道了脑瘫（CP）患儿股外侧肌活检的正常肌肉形态学。本报告将我们的正常活检结果与 BE 标准值标准进行了比较。
单盲前瞻性横断面研究设计。
CP 患儿的活检结果在形态计量学和光镜及电镜下均正常；然而，只有 10 例中的 5 例符合 BE 标准值标准。
这份简短的报告强调了需要从更多的活检中获得具有当代年龄特异性的正常数据，包括正常发育的儿童。文献回顾表明，可能可以从研究试验中的对照患儿中获得活检材料。这些形态计量学数据可以有助于扩大正常数据集。肌肉神经 59:590-590,2019。
