健康儿童和成年人的肌肉纤维大小与性别和纤维类型的关系。
Muscle fiber size in healthy children and adults in relation to sex and fiber types.
机构信息
Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
出版信息
Muscle Nerve. 2021 Apr;63(4):586-592. doi: 10.1002/mus.27151. Epub 2021 Jan 15.
BACKGROUND
In adult males, cross-sectional area (CSA) for type II muscle fibers is generally larger than for type I fibers. In this cross-sectional study the aim was to compare sex-related CSAs of various muscle fiber types during childhood-to-adulthood transition.
METHODS
Percutaneous biopsy samples were obtained from vastus lateralis in 10-y-old children (10 males and 5 females) and in young adults (9 males and 7 females). Fiber types were classified by myofibrillar ATPase and CSAs from NADH-dehydrogenase staining.
RESULTS
Type IIA were larger than type I fibers in adult males, but not in adult females or children (age x sex x fiber type, P < .002). When including all participants, body weight and sex explained 78% of the variation in type IIA CSA but only body weight contributed for type I.
CONCLUSIONS
Sex-specific patterns in CSA of the muscle fiber types appears to develop during the transition from childhood to adulthood.
背景
在成年男性中，II 型肌纤维的横截面积（CSA）通常大于 I 型纤维。在这项横断面研究中，我们的目的是比较儿童到成年过渡期各种肌纤维类型的性别相关 CSA。
方法
在 10 岁儿童（男性 10 名，女性 5 名）和年轻成年人（男性 9 名，女性 7 名）的股外侧进行经皮活检。通过肌球蛋白 ATP 酶和 NADH 脱氢酶染色对纤维类型进行分类。
结果
成年男性的 IIA 型纤维比 I 型纤维大，但成年女性和儿童则不然（年龄 x 性别 x 纤维类型，P <.002）。当包括所有参与者时，体重和性别解释了 IIA 型 CSA 变化的 78%，但只有体重对 I 型有贡献。
结论
从儿童到成年的过渡期间，肌肉纤维类型的 CSA 出现了性别特异性模式。
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