Liu Ye, Dan Yanjun, Yang Jiahong, He Xiaofeng, Liu Jingjing, Yi Yi, Chen Xing, Yin Xue, Song Weina, Niu Yueiqng, Zheng Yijie, Ai Yunfei
Department of Dermatology, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
L'Oréal Dermatological Beauty China, CeraVe, Shanghai, China.
J Cosmet Dermatol. 2025 Jul;24(7):e70353. doi: 10.1111/jocd.70353.
Acne vulgaris is a common skin condition characterized by excessive sebum production, inflammation, and compromised skin barrier function. Effective treatments should target both lesion reduction and skin hydration while maintaining tolerability.
This study aimed to evaluate the efficacy and tolerability of a salicylic acid-containing gel in reducing sebum levels, improving skin hydration, strengthening the skin barrier, and alleviating acne severity over 21 days.
A single-center, prospective clinical trial was conducted on 42 participants (37 females, 5 males, mean age: 25.86 ± 6.69 years) with mild-to-moderate acne (IGA grade 2-3) and oily or combination skin. Participants applied the gel twice daily for 21 days. Sebum levels (Sebumeter SM815), trans-epidermal water loss (TEWL, Tewameter TM Hex), and skin hydration (Corneometer CM825) were measured at multiple time points. Acne severity was assessed using the IGA scale, and self-reported satisfaction surveys were collected.
Following the follow-up period, sebum levels decreased by 23.65% (p < 0.05), while skin hydration increased by 40.5% (p < 0.05). TEWL decreased by 49.26% (p < 0.05), indicating enhanced skin barrier function. The IGA score improved by 23.81% (p < 0.001), demonstrating a significant reduction in acne severity. All participants (100%) reported satisfaction with the product, with notable improvements in oil control, acne reduction, and skin texture. The gel was well tolerated, with only 5% of participants reporting mild, transient itching, which resolved without intervention.
The salicylic acid-containing gel effectively reduces acne lesions, regulates sebum production, enhances skin hydration, and strengthens the skin barrier, making it a suitable option for acne-prone and sensitive skin. These findings suggest that the gel provides a well-balanced approach to acne treatment by addressing both clinical efficacy and user comfort.
寻常痤疮是一种常见的皮肤疾病，其特征为皮脂分泌过多、炎症以及皮肤屏障功能受损。有效的治疗应在保持耐受性的同时，兼顾减少皮损和皮肤保湿。
本研究旨在评估一种含水杨酸凝胶在21天内降低皮脂水平、改善皮肤保湿、强化皮肤屏障以及减轻痤疮严重程度方面的疗效和耐受性。
对42名患有轻度至中度痤疮（IGA分级2 - 3级）且为油性或混合性皮肤的参与者（37名女性，5名男性，平均年龄：25.86 ± 6.69岁）进行了一项单中心前瞻性临床试验。参与者每天涂抹凝胶两次，共21天。在多个时间点测量皮脂水平（皮脂仪SM815）、经表皮水分流失（TEWL，皮肤水分流失仪TM Hex）和皮肤保湿（角质层水合测量仪CM825）。使用IGA量表评估痤疮严重程度，并收集自我报告的满意度调查。
随访期结束后，皮脂水平下降了23.65%（p < 0.05），而皮肤保湿增加了40.5%（p < 0.05）。TEWL下降了49.26%（p < 0.05），表明皮肤屏障功能增强。IGA评分提高了23.81%（p < 0.001），显示痤疮严重程度显著降低。所有参与者（100%）对该产品表示满意，在控油、减少痤疮和改善皮肤质地方面有显著改善。该凝胶耐受性良好，只有5%的参与者报告有轻度、短暂的瘙痒，未经干预即自行缓解。
含水杨酸凝胶能有效减少痤疮皮损，调节皮脂分泌，增强皮肤保湿，并强化皮肤屏障，使其成为易长痤疮和敏感皮肤的合适选择。这些发现表明，该凝胶通过兼顾临床疗效和用户舒适度，为痤疮治疗提供了一种平衡的方法。
