Barillari P, Aurello P, De Angelis R, Gozzo P, Lolli E, Indinnimeo E M, Brozzetti S, Ramacciato G, Valabrega S, Barillari G
I Clinica Chirurgica, Università la Sapienza, Roma.
Ital J Surg Sci. 1988;18(3):237-41.
The role of tissue CEA localization as a complementary factor in prognosis of patients affected by gastric cancer is analyzed. In a group of 31 gastric tumors, tissue CEA was always present in the apical portion of the tumor cell cytoplasm and in the glandular lumen, while in 23 cases it was found in the stroma, and in superficial and deep cell cytoplasm in 26 and 20 cases respectively. The serum marker levels were over 3 ng/ml in 19 patients. A relationship between CEA localization and tumor stage was observed. The more the tumors were advanced, the more the marker was found in the stroma and in the cytoplasm of superficial and deep cells. The same was found for CEA localization and serum CEA levels. The opposite trend was evidenced for the degree of tumor differentiation. In well differentiated tumors in a high percentage of cases the marker was present in the stroma and in the cytoplasm of superficial and deep cells as compared with undifferentiated tumors. No relationship between the histologic type and CEA localization was found.
分析了组织癌胚抗原（CEA）定位在胃癌患者预后中作为补充因素的作用。在一组31例胃肿瘤中，组织CEA始终存在于肿瘤细胞质的顶端部分和腺腔内，而在23例中在间质中发现，分别在26例和20例的浅表和深层细胞质中发现。19例患者的血清标志物水平超过3 ng/ml。观察到CEA定位与肿瘤分期之间的关系。肿瘤进展程度越高，在间质以及浅表和深层细胞的细胞质中发现的标志物就越多。CEA定位和血清CEA水平也有同样的情况。肿瘤分化程度则呈现相反的趋势。与未分化肿瘤相比，在高比例的高分化肿瘤病例中，标志物存在于间质以及浅表和深层细胞的细胞质中。未发现组织学类型与CEA定位之间的关系。
