Santeusanio G, Peronace L, Castagna G, De Muro G, Santi D, D'Orazio A, Amanti C, Midiri G, Campisi C, D'Ambra G
Dipartimento di Biopatologia Umana, Universitá degli Studi di Roma, La Sapienza, Italy.
J Surg Oncol. 1988 Jan;37(1):13-9. doi: 10.1002/jso.2930370105.
The occurrence of carcinoembryonic antigen (CEA) was studied in 45 cases of gastric tumors by the immunoperoxidase technique. CEA-positive staining was found in 48.8% of tumors. A correlation was found between preoperative CEA values and tumor CEA staining. All patients with serum CEA values below 2.5 ng/ml showed CEA-negative staining of tumor. In patients with serum CEA values between 2.6 and 10 ng/ml, the tumors showed a minority of CEA-positive cells; but in patients with serum CEA values above 10 ng/ml, the tumors contained a majority of CEA-positive cells. CEA-positive staining was found in 34.4% of tumors of the diffuse type, and in 75% of tumors of the intestinal type. A high percentage of CEA positivity was seen in well-differentiated tumors (87.7%) compared to the moderately differentiated (69.2%), and to the undifferentiated (28.7%). A faint CEA-positivity was observed in intestinal metaplasia, while normal gastric mucosa was CEA-negative.
采用免疫过氧化物酶技术对45例胃肿瘤患者的癌胚抗原（CEA）表达情况进行了研究。在48.8%的肿瘤中发现了CEA阳性染色。术前CEA值与肿瘤CEA染色之间存在相关性。所有血清CEA值低于2.5 ng/ml的患者肿瘤均显示CEA阴性染色。血清CEA值在2.6至10 ng/ml之间的患者，肿瘤显示少数CEA阳性细胞；但血清CEA值高于10 ng/ml的患者，肿瘤含有多数CEA阳性细胞。弥漫型肿瘤中34.4%发现CEA阳性染色，肠型肿瘤中75%发现CEA阳性染色。与中分化（69.2%）和未分化（28.7%）肿瘤相比，高分化肿瘤中CEA阳性率较高（87.7%）。在肠化生中观察到微弱的CEA阳性，而正常胃黏膜CEA阴性。
