Dyachenko Pavel, Dyachenko Anatoly, Smiianova Olha, Kurhanskaya Victoria, Efremin Ruslan
Center Of Infectious Disorders Of The Nervous System, Si "L.V. Gromashevsky Institute Of Epidemiology And Infection Diseases Of Nams Of Ukraine", Kyiv, Ukraine.
Sumy State University, Sumy, Ukraine.
Wiad Lek. 2018;71(8):1636-1638.
Introduction: In this study, we investigated the possible involvement of Human herpesvirus 7 in multiple sclerosis. The aim: To contribute to clarifying the controversy on the association between Human Herpesviruses 7 (HHV-7) and multiple sclerosis (MS) studying patient with relapsing-remitting MS (RRMS).
Case study: Young female admitted to adult tertiary referral, infectious diseases hospital, Kyiv, Ukraine, with signs of a focal neurological deficit. Meningeal symptoms were not detected. The preadmission illness lasted some years. Clinical diagnosis was relapsing-remitting multiple sclerosis (RRMS). On admission, general condition was of moderate severity. She has a mild fever, confusion, speech and coordination disorders, dizziness, worsening of memory, inability to walk (inferior paraparesis). Focal lesions were detected on MRI scan. The spinal fluid contained oligoclonal IgG-chains and HHV-7 DNA. After two weeks of intensive antiviral treatment, the patient's condition improved significantly,the function of the lower limbs recovered almost completely, and she was discharged home.
Conclusion: Here we present a comprehensive clinical, radiological and virological analysis of the HHV-7-associated case of multiple sclerosis.
引言：在本研究中，我们调查了人类疱疹病毒7与多发性硬化症之间可能存在的关联。目的：通过对复发缓解型多发性硬化症（RRMS）患者的研究，为澄清人类疱疹病毒7（HHV-7）与多发性硬化症（MS）之间关联的争议做出贡献。
病例研究：一名年轻女性被收治于乌克兰基辅的一家成人三级转诊传染病医院，有局灶性神经功能缺损症状。未检测到脑膜症状。入院前疾病持续了数年。临床诊断为复发缓解型多发性硬化症（RRMS）。入院时，一般状况为中度严重。她有低热、意识模糊、言语和协调障碍、头晕、记忆力减退、无法行走（下肢轻瘫）。MRI扫描发现局灶性病变。脑脊液中含有寡克隆IgG链和HHV-7 DNA。经过两周的强化抗病毒治疗，患者病情显著改善，下肢功能几乎完全恢复，随后出院回家。
结论：在此，我们对HHV-7相关的多发性硬化症病例进行了全面的临床、影像学和病毒学分析。
