Ginzburg A L
Mol Gen Mikrobiol Virusol. 1988 Oct(10):3-9.
The literature on the molecular genetic mechanisms for antigenic variability of pathogenic bacteria is reviewed. Ability to antigenic variability in any case discussed is considered to be a pathogenicity factor permitting efficient struggle against the immune system of the host-organism. The molecular basis for such variability is instability of the genome structure, coding for highly immunogenic bacterial proteins.
本文综述了关于病原菌抗原变异性分子遗传机制的文献。在任何讨论的情况下,抗原变异性的能力都被认为是一种致病因素,它使病原菌能够有效地对抗宿主生物体的免疫系统。这种变异性的分子基础是编码高免疫原性细菌蛋白的基因组结构的不稳定性。