藻胆蛋白：分子结构、生产、应用及前景。

Phycobiliproteins: Molecular structure, production, applications, and prospects.

机构信息

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong 264003, China.

State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.

出版信息

Biotechnol Adv. 2019 Mar-Apr;37(2):340-353. doi: 10.1016/j.biotechadv.2019.01.008. Epub 2019 Jan 25.

DOI:10.1016/j.biotechadv.2019.01.008

PMID:30685481

Abstract

Phycobiliproteins (PBPs) are the main component of light-harvesting complexes in cyanobacteria and red algae. In addition to their important role in photosynthesis, PBPs have many potential applications in foods, cosmetics, medical diagnosis and treatment of diseases. However, basic researches and technological innovations are urgently needed for exploring those potentials, such as structure and function, their biosynthesis as well as downstream purification. For medical use and application, mechanisms underlying their therapeutic effects must be elucidated. Focusing on these issues, this article gives a critical review on the current status on PBPs, including their structures and functions, preparation processes and applications. In addition, key technical challenges and possible solutions are prospected.

摘要

藻胆蛋白（PBPs）是蓝藻和红藻中光捕获复合物的主要成分。除了在光合作用中的重要作用外，PBPs 在食品、化妆品、医学诊断和疾病治疗方面有许多潜在的应用。然而，为了探索这些潜力，如结构和功能、生物合成以及下游纯化等，还迫切需要进行基础研究和技术创新。对于医疗用途和应用，必须阐明其治疗效果的机制。本文围绕这些问题，对 PBPs 的研究现状进行了综述，包括其结构与功能、制备工艺及其应用。此外，还展望了关键技术挑战和可能的解决方案。