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偶然发现的脑膜瘤的临床病理特征:文献综述及罗切斯特大学尸检经验

Clinicopathologic features of incidental meningiomas: A review of the literature and the University of Rochester autopsy experience.

作者信息

Johnson Mahlon D, Abu-Farsakh Sohaib

出版信息

Clin Neuropathol. 2019 May/Jun;38(3):118-121. doi: 10.5414/NP301160.

DOI:10.5414/NP301160
PMID:30686285
Abstract

OBJECTIVE

Features of incidental meningiomas, found at autopsy, have not been extensively reported and may offer insight into their biology and management.

DESIGN

Review of the literature on unsuspected incidental antemortem and postmortem meningiomas and those from autopsies, at the University of Rochester from 2005 to 2016.

RESULTS

At autopsy, incidental meningiomas were usually found in 2 - 3% of cases. Incidental meningiomas found by neuroimaging were more commonly seen over the convexities, although our findings suggest that parasellar meningiomas are common. They are and are more commonly in males, WHO grade I, and fibrous or meningothelial, but our findings suggest psammomatous meningiomas are over-represented.

CONCLUSION: Incidental meningiomas are a relatively common unrecognized tumor. They are more likely to be in males, WHO grade I, parasellar, and with calcification.
.

摘要

目的

尸检时发现的偶然脑膜瘤的特征尚未得到广泛报道,可能有助于深入了解其生物学特性和治疗方法。

设计

回顾2005年至2016年罗切斯特大学关于生前未怀疑和死后发现的偶然脑膜瘤以及尸检脑膜瘤的文献。

结果

尸检时,偶然脑膜瘤通常在2%-3%的病例中发现。通过神经影像学发现的偶然脑膜瘤在脑凸面更常见,尽管我们的研究结果表明鞍旁脑膜瘤也很常见。它们更常见于男性、世界卫生组织I级、纤维型或脑膜皮型,但我们的研究结果表明砂粒体型脑膜瘤的比例过高。

结论

偶然脑膜瘤是一种相对常见的未被识别的肿瘤。它们更可能发生在男性、世界卫生组织I级、鞍旁且伴有钙化。

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Clinicopathologic features of incidental meningiomas: A review of the literature and the University of Rochester autopsy experience.偶然发现的脑膜瘤的临床病理特征:文献综述及罗切斯特大学尸检经验
Clin Neuropathol. 2019 May/Jun;38(3):118-121. doi: 10.5414/NP301160.
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Chrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells.大黄酸通过抑制骨桥蛋白/mTOR 并激活 NF2 信号通路,降低恶性脑膜瘤细胞的活力和增殖。
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