Department of Gastroenterology, Affiliated Hospital to Zunyi Medical College, Zunyi 563000, Guizhou Province, China.
World J Gastroenterol. 2019 Jan 21;25(3):287-299. doi: 10.3748/wjg.v25.i3.287.
The Na/Ca exchanger (NCX) protein family is a part of the cation/Ca exchanger superfamily and participates in the regulation of cellular Ca homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also mediates the development of digestive cancer, acute pancreatitis, and intestinal absorption. This review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments.
钠/钙交换器（NCX）蛋白家族是阳离子/Ca 交换器超家族的一部分，参与细胞内 Ca 稳态的调节。NCX1 是 NCX 家族中最重要的亚型，在哺乳动物的各种器官和组织中广泛表达，在神经和心血管系统的生理和病理过程中起着特别重要的作用。在过去的几年中，NCX1 在消化系统中的功能受到了越来越多的关注；NCX1 不仅参与了胃溃疡和胃黏膜损伤的愈合过程，还介导了消化性癌症、急性胰腺炎和肠道吸收的发展。本综述旨在探讨 NCX1 在消化系统生理学和病理生理学中的作用，以指导临床治疗。
