Liu Ming, Guo Fukun
Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Cincinnati, OH, USA.
Precis Clin Med. 2018 Sep;1(2):65-74. doi: 10.1093/pcmedi/pby011. Epub 2018 Sep 6.
Traditional cancer therapies include surgery, radiation, and chemotherapy, all of which are typically non-specific approaches. Cancer immunotherapy is a type of cancer treatment that helps the immune system fight cancer. Cancer immunotherapy represents a standing example of precision medicine: immune checkpoint inhibitors precisely target the checkpoints; tumor infiltrating lymphocytes, TCR T cells, and CAR T cells precisely kill cancer cells through tumor antigen recognition; and cancer vaccines are made from patient-derived dendritic cells, tumor cell DNA, or RNA, or oncolytic viruses, thus offering a type of personalized medicine. This review will highlight up-to-date advancement in most, if not all, of the immunotherapy strategies.
传统的癌症治疗方法包括手术、放疗和化疗,所有这些通常都是非特异性的方法。癌症免疫疗法是一种帮助免疫系统对抗癌症的癌症治疗类型。癌症免疫疗法是精准医学的一个典型例子:免疫检查点抑制剂精确靶向检查点;肿瘤浸润淋巴细胞、TCR T细胞和CAR T细胞通过肿瘤抗原识别精确杀死癌细胞;癌症疫苗由患者来源的树突状细胞、肿瘤细胞DNA或RNA或溶瘤病毒制成,因此提供了一种个性化医疗。本综述将重点介绍大多数(如果不是全部)免疫治疗策略的最新进展。