Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences , Jinan , Shandong , China.
Shandong Key Laboratory of Animal Disease control and Breeding , Jinan , Shandong , China.
Anim Biotechnol. 2019 Oct;30(4):352-357. doi: 10.1080/10495398.2018.1520716. Epub 2019 Jan 28.
Growth traits are mainly determined by genetic factors. SIRT4, a class II sirtuin, predominantly acts as an ADP-ribosyltransferase and inhibits fatty acid oxidation. In this study, a total of 1005 cattle belonging to five indigenous Chinese breeds were used to evaluate the relationship between the potential insertions/deletions (indels) within the SIRT4 gene and growth traits. The results revealed that only one intronic variation was present, which showed Hardy-Weinberg equilibrium ( > 0.05) in all the populations. The relationship analyses indicated that this indel was significantly associated with growth traits ( < 0.05), implying that significantly affects the growth traits. Therefore, the deletion mutation within the SIRT4 gene could be considered as a molecular marker to screen for growth traits in the cattle industry.
生长性状主要由遗传因素决定。SIRT4 是一种 II 类 sirtuin，主要作为 ADP-ribosyltransferase 发挥作用，并抑制脂肪酸氧化。本研究共使用了 1005 头属于五个中国本土品种的牛，以评估 SIRT4 基因内潜在插入/缺失（indels）与生长性状之间的关系。结果表明，所有群体中仅存在一个内含子变异，且处于 Hardy-Weinberg 平衡（ > 0.05）。关联分析表明，这种插入缺失与生长性状显著相关（ < 0.05），这表明它显著影响生长性状。因此，SIRT4 基因内的缺失突变可以作为筛选牛业中生长性状的分子标记。
