Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, China.
College of Life Sciences, Northwest A&F University, Xianyang 712100, China.
Genes (Basel). 2023 Jan 30;14(2):356. doi: 10.3390/genes14020356.
Marker-assisted selection is an important method for livestock breeding. In recent years, this technology has been gradually applied to livestock breeding to improve the body conformation traits. In this study, the (Leucine Rich Repeat Containing 8 VRAC Subunit B) gene was selected to evaluate the association between its genetic variations and the body conformation traits in two native sheep breeds in China. Four body conformation traits, including withers height, body length, chest circumference, and body weight, were collected from 269 Chaka sheep. We also collected the body length, chest width, withers height, chest depth, chest circumference, cannon bone circumference, and height at hip cross of 149 Small-Tailed Han sheep. Two different genotypes, ID and DD, were detected in all sheep. Our data showed that the polymorphism of the gene was significantly associated with chest depth ( < 0.05) in Small-Tailed Han sheep, and it is greater in sheep with DD than those with ID. In conclusion, our data suggested that the gene could serve as a candidate gene for marker-assisted selection in Small-Tailed Han sheep.
标记辅助选择是一种重要的家畜育种方法。近年来，这项技术已逐渐应用于家畜育种，以改善体躯结构性状。本研究选择富含亮氨酸重复序列 8 VRAC 亚基 B 基因，评估其遗传变异与中国两个本土绵羊品种体躯结构性状之间的关系。我们从 269 只察哈尔羊中收集了体高、体长、胸围和体重等 4 个体躯结构性状，还从 149 只小尾寒羊中收集了体长、胸宽、体高、胸深、胸围、管围和十字部高。所有绵羊均检测到两种不同基因型，ID 和 DD。我们的数据表明，基因的多态性与小尾寒羊的胸深显著相关（<0.05），DD 型的绵羊比 ID 型的绵羊更大。总之，我们的数据表明，该基因可以作为小尾寒羊标记辅助选择的候选基因。
