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镰状细胞病患者的蓝斑表现出比贫血对照组更大的功能连接性和中心性。

Patients with sickle-cell disease exhibit greater functional connectivity and centrality in the locus coeruleus compared to anemic controls.

机构信息

UCLA Pediatric Pain and Palliative Care Program, Division of Hematology-Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

UCLA Pediatric Pain and Palliative Care Program, Division of Hematology-Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

出版信息

Neuroimage Clin. 2019;21:101686. doi: 10.1016/j.nicl.2019.101686. Epub 2019 Jan 22.

DOI:10.1016/j.nicl.2019.101686
PMID:30690419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6356008/
Abstract

• Patients with sickle-cell disease (SCD) have greater resting-state functional connectivity between the locus coeruleus (LC) and dorsolateral prefrontal cortex (dlPFC). • Patients with SCD have greater resting state centrality of the LC. • SCD patients with chronic pain exhibited even greater functional connectivity between the LC and dlPFC. • This study supports hyper-connectivity between the LC and PFC is a potential chronic pain generator.

摘要

• 镰状细胞病 (SCD) 患者蓝斑 (LC) 和背外侧前额叶皮层 (dlPFC) 之间存在更大的静息状态功能连接。 • SCD 患者 LC 的静息状态中心度更大。 • 伴有慢性疼痛的 SCD 患者 LC 与 dlPFC 之间的功能连接甚至更强。 • 本研究支持 LC 与 PFC 之间的超连接是潜在的慢性疼痛发生机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6e/6356008/4384d2683807/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6e/6356008/6928bf5338a1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6e/6356008/c55d99f08313/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6e/6356008/89984e5fb306/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6e/6356008/4384d2683807/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6e/6356008/6928bf5338a1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6e/6356008/c55d99f08313/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6e/6356008/89984e5fb306/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c6e/6356008/4384d2683807/gr4.jpg

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