Nagaki Aiichiro, Yamashita Hiroki, Hirose Katsuyuki, Tsuchihashi Yuta, Yoshida Jun-Ichi
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie, 510-0294, Japan.
Angew Chem Int Ed Engl. 2019 Mar 18;58(12):4027-4030. doi: 10.1002/anie.201814088. Epub 2019 Feb 14.
Flash chemistry based on flow microreactor systems allowed alkyllithiums bearing electrophilic functional groups to be successfully generated and used for subsequent reactions. The series of reactions with high reactivity was achieved by extremely accurate control over residence time in a controlled and selective manner.
基于流动微反应器系统的快速化学方法能够成功生成带有亲电官能团的烷基锂，并将其用于后续反应。通过以可控且选择性的方式对停留时间进行极其精确的控制，实现了这一系列具有高反应活性的反应。
