Nagaki Aiichiro, Takahashi Yusuke, Yoshida Jun-ichi
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727.
Chemistry. 2014 Jun 23;20(26):7931-4. doi: 10.1002/chem.201402520. Epub 2014 May 23.
Carboxylation of short-lived organolithiums bearing electrophilic functional groups such as nitro, cyano, and alkoxycarbonyl groups with CO2 to give carboxylic acids and active esters was accomplished in a flow microreactor system. The successful reactions indicate that gas/liquid mass transfer and the subsequent chemical reaction with CO2 are extremely fast.
在流动微反应器系统中，实现了带有亲电官能团（如硝基、氰基和烷氧羰基）的短寿命有机锂与二氧化碳的羧化反应，生成羧酸和活性酯。成功的反应表明气/液传质以及随后与二氧化碳的化学反应极快。
