Kotewall Nicholas, Lang Brian H H
Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.
Ultrasonography. 2019 Apr;38(2):135-142. doi: 10.14366/usg.18040. Epub 2018 Nov 9.
High-intensity focused ultrasound (HIFU) is a promising ablation technique for benign thyroid nodules. Current evidence has found good short- to medium-term outcomes, similar to those of better-established ablation techniques such as radiofrequency and laser ablation. The fact that it does not require insertion of a needle into the target makes HIFU a truly non-invasive treatment. Although it is not without risks, its low risk profile makes it an attractive alternative to surgery. There is much room for future development, starting from expanding the current indications to enhancing energy delivery. Relapsed Graves disease and papillary microcarcinoma are diseases that can benefit from HIFU treatment. Its role in the mediation of immune responses and synergistic effects with immunotherapy are promising in the fight against metastatic cancers.
高强度聚焦超声（HIFU）是一种用于良性甲状腺结节的有前景的消融技术。目前的证据表明，其短期至中期效果良好，与射频和激光消融等更成熟的消融技术相似。HIFU无需将针插入目标组织，这使其成为一种真正的非侵入性治疗方法。尽管它并非没有风险，但其低风险特征使其成为手术的有吸引力的替代方案。从扩大当前适应症到增强能量传递，未来有很大的发展空间。复发性格雷夫斯病和乳头状微癌是可从HIFU治疗中获益的疾病。它在免疫反应调节以及与免疫疗法的协同效应方面在对抗转移性癌症中具有前景。
