Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians University Munich, D-82152 Martinsried, Germany.
The Feinstein Institute for Medical Research, The Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Northwell Health System, Manhasset, NY 11030, USA.
Cells. 2019 Jan 27;8(2):90. doi: 10.3390/cells8020090.
Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyelitis optica spectrum disorder (NMOSD). Emerging data suggest that AQP4 may also be implicated in the glymphatic system and may be involved in the clearance of beta-amyloid in Alzheimer's disease (AD). In this review, we will describe the role of AQP4 in the adult and developing brain as well as its implication for disease.
水通道蛋白 4（AQP4）是一种在大脑星形胶质细胞足突上表达的水通道蛋白。AQP4 的作用在健康和一系列病理条件下都有研究。自从发现 AQP4 是炎症性自身免疫性疾病视神经脊髓炎谱系障碍（NMOSD）的靶抗原以来，人们对 AQP4 的兴趣日益增加。新出现的数据表明，AQP4 也可能与神经胶质淋巴系统有关，并可能参与阿尔茨海默病（AD）中β-淀粉样蛋白的清除。在这篇综述中，我们将描述 AQP4 在成人和发育中的大脑中的作用及其对疾病的影响。
