CrossTalk proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin-4.
作者信息
Iliff Jeffrey, Simon Matthew
机构信息
VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA.
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
出版信息
J Physiol. 2019 Sep;597(17):4417-4419. doi: 10.1113/JP277635. Epub 2019 Aug 6.
Abstract
摘要
相似文献
1
CrossTalk proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin-4.
J Physiol. 2019 Sep;597(17):4417-4419. doi: 10.1113/JP277635. Epub 2019 Aug 6.
2
Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Elife. 2018 Dec 18;7:e40070. doi: 10.7554/eLife.40070.
3
Detection of Glymphatic Outflow of Tau from Brain to Cerebrospinal Fluid in Mice.
Methods Mol Biol. 2024;2754:351-359. doi: 10.1007/978-1-0716-3629-9_19.
4
Circadian control of brain glymphatic and lymphatic fluid flow.
Nat Commun. 2020 Sep 2;11(1):4411. doi: 10.1038/s41467-020-18115-2.
5
Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.
Brain. 2020 Aug 1;143(8):2576-2593. doi: 10.1093/brain/awaa179.
6
Acute systemic LPS-exposure impairs perivascular CSF distribution in mice.
J Neuroinflammation. 2021 Jan 29;18(1):34. doi: 10.1186/s12974-021-02082-6.
7
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.
Elife. 2023 Feb 9;12:e82232. doi: 10.7554/eLife.82232.
8
Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271.
Glia. 2024 May;72(5):982-998. doi: 10.1002/glia.24515. Epub 2024 Feb 16.
9
The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system?
Acta Neuropathol. 2018 Mar;135(3):387-407. doi: 10.1007/s00401-018-1812-4. Epub 2018 Feb 10.
10
Cocaine-induced structural and functional impairments of the glymphatic pathway in mice.
Brain Behav Immun. 2020 Aug;88:97-104. doi: 10.1016/j.bbi.2020.04.057. Epub 2020 Apr 23.
引用本文的文献
1
Brain water dynamics across sleep stages measured by near-infrared spectroscopy: Implications for glymphatic function.
J Cereb Blood Flow Metab. 2025 Jun 25:271678X251353142. doi: 10.1177/0271678X251353142.
2
Covert cerebrospinal fluid dynamics dysfunction: evolution from conventional to innovative therapies.
Front Neurol. 2025 Mar 12;16:1554813. doi: 10.3389/fneur.2025.1554813. eCollection 2025.
3
Glymphatic dysfunction in multiple sclerosis and its association with disease pathology and disability.
Mult Scler. 2024 Nov;30(13):1609-1619. doi: 10.1177/13524585241280842. Epub 2024 Sep 29.
4
Accumulation of Cerebrospinal Fluid, Ventricular Enlargement, and Cerebral Folate Metabolic Errors Unify a Diverse Group of Neuropsychiatric Conditions Affecting Adult Neocortical Functions.
Int J Mol Sci. 2024 Sep 23;25(18):10205. doi: 10.3390/ijms251810205.
5
Astrocyte regulation of extracellular space parameters across the sleep-wake cycle.
Front Cell Neurosci. 2024 Jun 26;18:1401698. doi: 10.3389/fncel.2024.1401698. eCollection 2024.
6
Alterations in brain fluid physiology during the early stages of development of ischaemic oedema.
Fluids Barriers CNS. 2024 Jun 10;21(1):51. doi: 10.1186/s12987-024-00534-8.
7
Neuropathogenesis-on-chips for neurodegenerative diseases.
Nat Commun. 2024 Mar 12;15(1):2219. doi: 10.1038/s41467-024-46554-8.
8
Iron Overload in Brain: Transport Mismatches, Microbleeding Events, and How Nanochelating Therapies May Counteract Their Effects.
Int J Mol Sci. 2024 Feb 16;25(4):2337. doi: 10.3390/ijms25042337.
9
Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms.
Sci Rep. 2024 Jan 26;14(1):2250. doi: 10.1038/s41598-023-51069-1.
10
Neuron-astrocyte omnidirectional signaling in neurological health and disease.
Front Mol Neurosci. 2023 Jun 8;16:1169320. doi: 10.3389/fnmol.2023.1169320. eCollection 2023.
本文引用的文献
1
Analysis of convective and diffusive transport in the brain interstitium.
Fluids Barriers CNS. 2019 Mar 6;16(1):6. doi: 10.1186/s12987-019-0126-9.
2
Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.
Sci Adv. 2019 Feb 27;5(2):eaav5447. doi: 10.1126/sciadv.aav5447. eCollection 2019 Feb.
3
Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Elife. 2018 Dec 18;7:e40070. doi: 10.7554/eLife.40070.
4
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.
Nat Commun. 2018 Nov 19;9(1):4878. doi: 10.1038/s41467-018-07318-3.
5
Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology.
Sci Rep. 2018 Aug 17;8(1):12389. doi: 10.1038/s41598-018-30779-x.
6
Is bulk flow plausible in perivascular, paravascular and paravenous channels?
Fluids Barriers CNS. 2018 Jun 15;15(1):17. doi: 10.1186/s12987-018-0103-8.
7
Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue.
Cell. 2018 Feb 22;172(5):1108-1121.e15. doi: 10.1016/j.cell.2018.02.007.
8
Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery.
J Physiol. 2018 Feb 1;596(3):445-475. doi: 10.1113/JP275105. Epub 2017 Dec 18.
9
Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow.
Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9894-9899. doi: 10.1073/pnas.1706942114. Epub 2017 Aug 28.
10
Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma.
Elife. 2017 Aug 21;6:e27679. doi: 10.7554/eLife.27679.
Zotero 插件