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1
Development of ulcerative colitis under the immunosuppressive effect of cyclosporine.在环孢素免疫抑制作用下溃疡性结肠炎的发展
Clin Investig. 1992 Jul;70(7):611-3. doi: 10.1007/BF00184805.
2
Drug therapy of inflammatory bowel disease.炎症性肠病的药物治疗
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Cyclosporine A for induction of remission in severe ulcerative colitis.环孢素A用于诱导重症溃疡性结肠炎缓解
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Measurement of colonic tissue cyclosporine concentration in children with severe ulcerative colitis.重度溃疡性结肠炎患儿结肠组织中环孢素浓度的测定。
J Pediatr Gastroenterol Nutr. 1992 Aug;15(2):125-9. doi: 10.1097/00005176-199208000-00004.
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Z Gastroenterol. 2005 Feb;43(2):195-9. doi: 10.1055/s-2004-813743.
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Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis.静脉注射环孢素与静脉注射皮质类固醇作为溃疡性结肠炎严重发作的单一疗法。
Gastroenterology. 2001 May;120(6):1323-9. doi: 10.1053/gast.2001.23983.

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Crohn's ileitis after liver transplantation from a living related donor with Crohn's disease.来自患有克罗恩病的活体亲属供体的肝移植后发生的克罗恩回肠炎。
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本文引用的文献

1
Cyclosporin in ulcerative colitis.环孢素治疗溃疡性结肠炎
Lancet. 1984 Dec 1;2(8414):1277-8. doi: 10.1016/s0140-6736(84)92826-5.
2
[Cyclosporin A in acute Crohn disease: initial findings].[环孢素A治疗急性克罗恩病：初步研究结果]
Schweiz Med Wochenschr. 1986 Jul 19;116(29):962-3.
3
Treatment of Crohn's disease in relapse with cyclosporin A.用环孢素A治疗克罗恩病复发
Br J Surg. 1988 Dec;75(12):1185-8. doi: 10.1002/bjs.1800751213.
4
Infectious diarrhea in human immunodeficiency virus infection.人类免疫缺陷病毒感染中的感染性腹泻
Gastroenterol Clin North Am. 1988 Sep;17(3):587-98.
5
Remission of Crohn's disease after human immunodeficiency virus infection.人类免疫缺陷病毒感染后克罗恩病的缓解
Gastroenterology. 1988 Dec;95(6):1667-9. doi: 10.1016/s0016-5085(88)80094-5.
6
The immunologic basis of inflammatory bowel disease.炎症性肠病的免疫学基础。
J Clin Immunol. 1986 Nov;6(6):415-32. doi: 10.1007/BF00915248.
7
Cyclosporin A treatment in inflammatory bowel disease.
Dig Dis Sci. 1989 Sep;34(9):1387-92. doi: 10.1007/BF01538074.
8
Unsatisfactory effect of cyclosporin A treatment in Crohn's disease: a report of five cases.环孢素A治疗克罗恩病效果欠佳：5例报告
J Intern Med. 1989 Sep;226(3):157-61. doi: 10.1111/j.1365-2796.1989.tb01373.x.
9
A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease.一项关于环孢素治疗活动性慢性克罗恩病的安慰剂对照、双盲、随机试验。
N Engl J Med. 1989 Sep 28;321(13):845-50. doi: 10.1056/NEJM198909283211301.
10
Oral administration of cyclosporin does not prevent expansion of antigen-specific, gut-associated, and spleen lymphocyte populations during Chlamydia trachomatis proctitis in nonhuman primates.在非人灵长类动物的沙眼衣原体直肠炎期间，口服环孢素并不能阻止抗原特异性、肠道相关及脾脏淋巴细胞群体的扩增。
Dig Dis Sci. 1989 Apr;34(4):585-95. doi: 10.1007/BF01536337.

在环孢素免疫抑制作用下溃疡性结肠炎的发展

Development of ulcerative colitis under the immunosuppressive effect of cyclosporine.

作者信息

Passfall J, Distler A, Riecken E O, Zeitz M

机构信息

Abteilung für Allgemeine Innere Medizin und Nephrologie und, Freie Universität Berlin.

出版信息

Clin Investig. 1992 Jul;70(7):611-3. doi: 10.1007/BF00184805.

DOI:10.1007/BF00184805
PMID:1356531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7087535/
Abstract

In recent studies, cyclosporine has been used for the treatment of both ulcerative colitis and Crohn's disease. The results of these studies were variable. We report on a patient who was treated for 6 years with cyclosporine after kidney transplantation. He developed chronic distal colitis with all the features of ulcerative colitis. An infectious etiology of the colitis was carefully excluded. High-dose treatment with methylprednisolone was required to induce remission. This report shows that immunosuppressive therapy with cyclosporine did not prevent the development of ulcerative colitis in this patient.

摘要

在最近的研究中，环孢素已被用于治疗溃疡性结肠炎和克罗恩病。这些研究的结果各不相同。我们报告了一名肾移植后接受环孢素治疗6年的患者。他患上了具有溃疡性结肠炎所有特征的慢性远端结肠炎。已仔细排除结肠炎的感染性病因。需要用甲泼尼龙进行高剂量治疗以诱导缓解。本报告表明，该患者接受环孢素免疫抑制治疗未能预防溃疡性结肠炎的发生。