Casalino Giuseppe, Sivagnanavel Vasuki, Dowlut Samir, Keane Pearse A, Chakravarthy Usha
1Royal Eye Unit, Kingston Hospital NHS Foundation Trust, London, UK.
2Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Int J Retina Vitreous. 2019 Jan 23;5:4. doi: 10.1186/s40942-019-0155-1. eCollection 2019.
To report the clinical course and the multimodal retinal imaging of a spontaneous retinal pigment epithelial (RPE) tear in a type 2 choroidal neovascularization (CNV) secondary to age-related macular degeneration treated with anti-vascular endothelial growth factor (VEGF) treatment.
A 74 year-old man presented with visual acuity deterioration in the right eye. Multimodal retinal imaging showed a predominantly classic (type 2) CNV complicated by a spontaneous RPE tear. The patient received six intravitreal injections of anti-VEGF which resulted in improvement of the vision and stabilization of the neovascular lesion on optical coherence tomography (OCT). Longitudinal changes of the RPE-photoreceptors interface, including RPE splitting, are reported on OCT.
RPE tears may spontaneously occur in type 2 CNV. Anti-VEGF treatment should be aimed at promoting RPE repair and limiting the extent of the scarring. The mechanisms of RPE repair during treatment may be documented with OCT.
报告一例年龄相关性黄斑变性继发2型脉络膜新生血管（CNV）并接受抗血管内皮生长因子（VEGF）治疗的患者发生自发性视网膜色素上皮（RPE）撕裂的临床过程及多模式视网膜成像情况。
一名74岁男性因右眼视力下降就诊。多模式视网膜成像显示主要为典型（2型）CNV，并伴有自发性RPE撕裂。患者接受了6次玻璃体内抗VEGF注射，视力得到改善，光学相干断层扫描（OCT）显示新生血管病变稳定。报告了OCT上RPE - 光感受器界面的纵向变化，包括RPE分裂。
2型CNV可能会自发发生RPE撕裂。抗VEGF治疗应旨在促进RPE修复并限制瘢痕形成范围。治疗期间RPE修复的机制可用OCT记录。
