College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128 Hunan, China.
Animal Science Division, Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Sciences (NIAB-C, PIEAS), Faisalabad 38000, Pakistan.
Mediators Inflamm. 2021 Sep 27;2021:9962860. doi: 10.1155/2021/9962860. eCollection 2021.
It has been widely known that oxidative stress disrupts the balance between reactive oxygen species (ROS) and the antioxidant system in the body. During pregnancy, the physiological generation of ROS is involved in a variety of developmental processes ranging from oocyte maturation to luteolysis and embryo implantation. While abnormal overproduction of ROS disrupts these processes resulting in reproductive failure. In addition, excessive oxidative stress impairs maternal and placental functions and eventually results in fetal loss, IUGR, and gestational diabetes mellitus. Although some oxidative stress is inevitable during pregnancy, a balancing act between oxidant and antioxidant production is necessary at different stages of the pregnancy. The review aims to highlight the importance of maintaining oxidative and antioxidant balance throughout pregnancy. Furthermore, we highlight the role of oxidative stress in pregnancy-related diseases.
众所周知，氧化应激会破坏体内活性氧（ROS）和抗氧化系统之间的平衡。在怀孕期间，ROS 的生理产生涉及到从卵母细胞成熟到黄体溶解和胚胎着床的各种发育过程。然而，ROS 的异常过度产生会破坏这些过程，导致生殖失败。此外，过度的氧化应激会损害母体和胎盘的功能，最终导致胎儿丢失、胎儿生长受限和妊娠期糖尿病。虽然怀孕期间不可避免地会产生一些氧化应激，但在妊娠的不同阶段，氧化剂和抗氧化剂的产生之间需要保持平衡。本综述旨在强调在整个怀孕期间维持氧化和抗氧化平衡的重要性。此外，我们还强调了氧化应激在与妊娠相关疾病中的作用。
