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用于扩展可见光光化学反应的激光驱动流动化学平台。

A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light.

作者信息

Harper Kaid C, Moschetta Eric G, Bordawekar Shailendra V, Wittenberger Steven J

机构信息

Process Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.

出版信息

ACS Cent Sci. 2019 Jan 23;5(1):109-115. doi: 10.1021/acscentsci.8b00728. Epub 2019 Jan 7.

DOI:10.1021/acscentsci.8b00728
PMID:30693330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6346387/
Abstract

Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multikilogram production. We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high-intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer-Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochemical reactions.

摘要

可见光促进的有机反应可以通过独特的反应途径提高反应活性和选择性，以解决众多实际合成问题，但将这些反应用于多千克规模生产的实际解决方案却很少。我们开发了一种简单且通用的连续搅拌釜式反应器（CSTR），该反应器配备了高强度激光，能够以前所未有的速率在连续流动中驱动光化学反应，使用100 mL反应器实现了每天数千克的产量。我们的流动反应器设计方法以比尔-朗伯定律为指导，优化催化剂浓度和反应器深度以实现最大产量。这种激光CSTR平台及其设计原理可应用于广泛的光化学反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/1a632b359d5d/oc-2018-00728y_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/6e97f562d082/oc-2018-00728y_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/3c608667e885/oc-2018-00728y_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/7e89ff5a69bb/oc-2018-00728y_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/32b92caef62c/oc-2018-00728y_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/1a632b359d5d/oc-2018-00728y_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/6e97f562d082/oc-2018-00728y_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/3c608667e885/oc-2018-00728y_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/7e89ff5a69bb/oc-2018-00728y_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/32b92caef62c/oc-2018-00728y_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/155b/6346387/1a632b359d5d/oc-2018-00728y_0005.jpg

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