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合成有机化学家的流动化学实地指南。

A field guide to flow chemistry for synthetic organic chemists.

作者信息

Capaldo Luca, Wen Zhenghui, Noël Timothy

机构信息

Flow Chemistry Group, Van 't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam 1098 XH Amsterdam The Netherlands

出版信息

Chem Sci. 2023 Mar 15;14(16):4230-4247. doi: 10.1039/d3sc00992k. eCollection 2023 Apr 26.

Abstract

Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea that it is a mysterious "black box" needs to go. In this review, we show that several of the benefits of microreactor technology can be exploited to push the boundaries in organic synthesis and to unleash unique reactivity and selectivity. By "lifting the veil" on some of the governing principles behind the observed trends, we hope that this review will serve as a useful field guide for those interested in diving into flow chemistry.

摘要

流动化学为合成领域开启了一个充满可能性的世界,但认为它是一个神秘“黑匣子”的观念需要摒弃。在本综述中,我们表明微反应器技术的一些优势可被利用来拓展有机合成的边界,并释放独特的反应活性和选择性。通过“揭开”一些观察到的趋势背后的主导原理的“面纱”,我们希望本综述能为那些有兴趣深入研究流动化学的人提供一份有用的领域指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef66/10132167/48cfa5eab5e2/d3sc00992k-f1.jpg

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