Liu Haidong, Ge Liang, Wang Ding-Xing, Chen Nan, Feng Chao
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu, 210009, P. R. China.
Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3918-3922. doi: 10.1002/anie.201814308. Epub 2019 Feb 13.
A novel strategy for the expedient construction of CF -embeded tertiary/quarternary carbon centers was developed by taking advantage of photoredox catalysis. Thanks to a key step of single-electron oxidation, electron-rich gem-difluoroalkenes, which otherwise are essentially reluctant towards F-nucleoplilic addition, now readily participate in this fluoroallylation reaction. Furthermore, this strategy provides an elegant example for the generation, as well as functionalization, of α-CF -substituted benzylic radical intermediates using cheap and readily available starting materials.
利用光氧化还原催化作用，开发了一种快速构建含CF的叔/季碳中心的新策略。由于单电子氧化的关键步骤，原本基本上不愿意进行氟亲核加成的富电子偕二氟烯烃，现在很容易参与这种氟代烯丙基化反应。此外该策略还提供了一个很好的例子，即使用廉价且容易获得的起始原料来生成α-CF取代的苄基自由基中间体并对其进行官能团化。
