Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Alberta, CANADA.
Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, CANADA.
Med Sci Sports Exerc. 2019 May;51(5):930-940. doi: 10.1249/MSS.0000000000001890.
To prescribe different physical activity (PA) intensities using activity trackers to increase PA, reduce sedentary time, and improve health outcomes among breast cancer survivors. The maintenance effect of the interventions on study outcomes was also assessed.
The Breast Cancer and Physical Activity Level pilot trial randomized 45 breast cancer survivors to a home-based, 12-wk lower (300 min·wk at 40%-59% of HR reserve) or higher-intensity PA (150 min·wk at 60%-80% of HR reserve), or no PA intervention/control. Both intervention groups received Polar A360® activity trackers. Study outcomes assessed at baseline, 12 and 24 wk included PA and sedentary time (ActiGraph GT3X+), health-related fitness (e.g., body composition, cardiopulmonary fitness/V˙O2max), and patient-reported outcomes (e.g., quality of life). Intention-to-treat analyses were conducted using linear mixed models and adjusted for baseline outcomes.
Increases in moderate-vigorous intensity PA (least squares adjusted group difference [LSAGD], 0.6; 95% confidence interval [CI], 0.1-1.0) and decreases in sedentary time (LSAGD, -1.2; 95% CI, -2.2 to -0.2) were significantly greater in the lower-intensity PA group versus control at 12 wk. Increases in V˙O2max at 12 wk in both interventions groups were significantly greater than changes in the control group (lower-intensity PA group LSAGD, 4.2; 95% CI, 0.5-8.0 mL·kg·min; higher-intensity PA group LSAGD, 5.4; 95% CI, 1.7-9.1 mL·kg·min). Changes in PA and V˙O2max remained at 24 wk, but differences between the intervention and control groups were no longer statistically significant.
Increases in PA time and cardiopulmonary fitness/V˙O2max can be achieved with both lower- and higher-intensity PA interventions in breast cancer survivors. Reductions in sedentary time were also noted in the lower-intensity PA group.
使用活动追踪器为乳腺癌幸存者规定不同的身体活动（PA）强度，以增加 PA，减少久坐时间，并改善健康结果。还评估了干预措施对研究结果的维持效果。
乳腺癌和体力活动水平的初步试验将 45 名乳腺癌幸存者随机分配到家庭基础、12 周的低强度 PA（300 分钟·周，HR 储备的 40%-59%）或高强度 PA（150 分钟·周，HR 储备的 60%-80%），或不进行 PA 干预/对照组。两个干预组都接受了 Polar A360®活动追踪器。基线、12 周和 24 周评估的研究结果包括 PA 和久坐时间（ActiGraph GT3X+）、与健康相关的体能（例如，身体成分、心肺功能/V˙O2max）和患者报告的结果（例如，生活质量）。使用线性混合模型进行意向治疗分析，并根据基线结果进行调整。
在 12 周时，低强度 PA 组与对照组相比，中度至剧烈强度 PA（最小二乘调整组差异[LSAGD]，0.6；95%置信区间[CI]，0.1-1.0）增加，久坐时间减少（LSAGD，-1.2；95% CI，-2.2 至-0.2）。在 12 周时，两个干预组的 V˙O2max 均明显高于对照组的变化（低强度 PA 组 LSAGD，4.2；95% CI，0.5-8.0 毫升·千克·分钟；高强度 PA 组 LSAGD，5.4；95% CI，1.7-9.1 毫升·千克·分钟）。PA 和 V˙O2max 的变化在 24 周时仍保持不变，但干预组与对照组之间的差异不再具有统计学意义。
在乳腺癌幸存者中，低强度和高强度 PA 干预都可以增加 PA 时间和心肺功能/V˙O2max，并且在低强度 PA 组中还观察到久坐时间减少。
