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巨细胞动脉炎:早期诊断是关键。

Giant cell arteritis: early diagnosis is key.

作者信息

Baig Iyza F, Pascoe Alexis R, Kini Ashwini, Lee Andrew G

机构信息

McGovern Medical School, The University of Texas Health Science Center in Houston, Houston, TX, USA.

Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA,

出版信息

Eye Brain. 2019 Jan 17;11:1-12. doi: 10.2147/EB.S170388. eCollection 2019.

DOI:10.2147/EB.S170388
PMID:30697092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6340646/
Abstract

Giant cell arteritis (GCA) is an inflammatory vasculitis typically affecting elderly that can potentially cause vision loss. Studies have demonstrated that early recognition and initiation of treatment can improve visual prognosis in patients with GCA. This review addresses the benefits of early diagnosis and treatment, and discusses the available treatment options to manage the disease.

摘要

巨细胞动脉炎(GCA)是一种通常影响老年人的炎症性血管炎,可能导致视力丧失。研究表明,早期识别和开始治疗可改善GCA患者的视力预后。本综述阐述了早期诊断和治疗的益处,并讨论了用于管理该疾病的现有治疗选择。

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Giant cell arteritis: early diagnosis is key.巨细胞动脉炎:早期诊断是关键。
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Open Access Rheumatol. 2025 Jul 1;17:117-134. doi: 10.2147/OARRR.S517664. eCollection 2025.
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Impact of early treatment on the relapse-free survival and glucocorticoid dosing in giant cell arteritis: a retrospective cohort study.

本文引用的文献

1
Ultrasound in the diagnosis and management of giant cell arteritis.超声在巨细胞动脉炎的诊断和治疗中的应用。
Rheumatology (Oxford). 2018 Feb 1;57(suppl_2):ii22-ii31. doi: 10.1093/rheumatology/kex461.
2
Prevention of glucocorticoid morbidity in giant cell arteritis.巨细胞动脉炎中糖皮质激素发病的预防。
Rheumatology (Oxford). 2018 Feb 1;57(suppl_2):ii11-ii21. doi: 10.1093/rheumatology/kex459.
3
Pathologic Markers Determining Prognosis in Patients With Treated or Healing Giant Cell Arteritis.治疗或愈合的巨细胞动脉炎患者的病理标志物与预后的关系。
早期治疗对巨细胞动脉炎无复发生存率和糖皮质激素剂量的影响:一项回顾性队列研究
Clin Rheumatol. 2025 Aug;44(8):3277-3283. doi: 10.1007/s10067-025-07560-3. Epub 2025 Jul 5.
4
Utilising multiple discharge coding will improve identification of patients with giant cell arteritis: a retrospective analysis of a hospital discharge dataset.使用多重出院编码将改善巨细胞动脉炎患者的识别:一项医院出院数据集的回顾性分析
Rheumatol Int. 2025 Feb 21;45(3):58. doi: 10.1007/s00296-025-05814-6.
5
A Machine Learning Model Based on Radiomic Features as a Tool to Identify Active Giant Cell Arteritis on [F]FDG-PET Images During Follow-Up.一种基于放射组学特征的机器学习模型作为在随访期间通过[F]FDG-PET图像识别活动性巨细胞动脉炎的工具。
Diagnostics (Basel). 2025 Feb 4;15(3):367. doi: 10.3390/diagnostics15030367.
6
An in-depth comparison of vascular inflammation on ultrasound, FDG-PET/CT and MRI in patients with suspected giant cell arteritis.疑似巨细胞动脉炎患者血管炎症在超声、氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)及磁共振成像(MRI)上的深入比较
Eur J Nucl Med Mol Imaging. 2025 Feb 4. doi: 10.1007/s00259-025-07088-3.
7
Silent Inflammation: A Case of Blurry Vision Raising Diagnostic Challenges in an Elderly Patient.隐匿性炎症:一例视力模糊给老年患者诊断带来挑战的病例
Cureus. 2024 Nov 30;16(11):e74822. doi: 10.7759/cureus.74822. eCollection 2024 Nov.
8
Investigating interferon type I responses in patients with suspected giant cell arteritis and polymyalgia rheumatica.探讨怀疑巨细胞动脉炎和多发性肌痛症患者的 I 型干扰素反应。
Clin Exp Immunol. 2024 Nov 12;218(3):308-313. doi: 10.1093/cei/uxae085.
9
Giant Cell Arteritis Masquerading as Tooth Pain: A Case Report.伪装成牙痛的巨细胞动脉炎:一例报告
Cureus. 2024 Apr 8;16(4):e57836. doi: 10.7759/cureus.57836. eCollection 2024 Apr.
10
Comparing Diagnostic Performance of Short and Long [F]FDG-PET Acquisition Times in Giant Cell Arteritis.比较短时间和长时间[F]FDG-PET采集时间在巨细胞动脉炎中的诊断性能
Diagnostics (Basel). 2023 Dec 27;14(1):62. doi: 10.3390/diagnostics14010062.
Am J Ophthalmol. 2018 Sep;193:45-53. doi: 10.1016/j.ajo.2018.05.031. Epub 2018 Jun 8.
4
FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC.FDG-PET/CT(A)成像在大血管血管炎和巨细胞动脉炎中的应用:EANM、SNMMI 和 PET 兴趣小组(PIG)的联合程序建议,并得到 ASNC 的认可。
Eur J Nucl Med Mol Imaging. 2018 Jul;45(7):1250-1269. doi: 10.1007/s00259-018-3973-8. Epub 2018 Apr 11.
5
Negative temporal artery biopsy: predictive factors for giant cell arteritis diagnosis and alternate diagnoses of patients without arteritis.阴性颞动脉活检:巨细胞动脉炎诊断的预测因素以及无动脉炎患者的其他诊断。
Clin Rheumatol. 2018 Oct;37(10):2819-2824. doi: 10.1007/s10067-018-4068-4. Epub 2018 Mar 17.
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Tocilizumab in Giant Cell Arteritis: A Real-Life Retrospective Study.托珠单抗治疗巨细胞动脉炎:一项真实世界回顾性研究。
Angiology. 2018 Oct;69(9):763-769. doi: 10.1177/0003319717753223. Epub 2018 Jan 17.
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Trial of Tocilizumab in Giant-Cell Arteritis.托珠单抗治疗巨细胞动脉炎的试验
N Engl J Med. 2017 Oct 12;377(15):1493. doi: 10.1056/NEJMc1711031.
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Trial of Tocilizumab in Giant-Cell Arteritis.托珠单抗治疗巨细胞动脉炎的临床试验。
N Engl J Med. 2017 Jul 27;377(4):317-328. doi: 10.1056/NEJMoa1613849.
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Diagnostic validity of Doppler ultrasound in giant cell arteritis.多普勒超声在巨细胞动脉炎中的诊断效度
Clin Exp Rheumatol. 2017 Mar-Apr;35 Suppl 103(1):123-127. Epub 2017 Feb 28.
10
A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Giant Cell Arteritis.阿巴西普(CTLA-4Ig)治疗巨细胞动脉炎的随机、双盲试验。
Arthritis Rheumatol. 2017 Apr;69(4):837-845. doi: 10.1002/art.40044. Epub 2017 Mar 3.