Applied BioMath LLC, Oakland, California, USA.
The American Society of Clinical Pharmacology and Therapeutics Quantitative Pharmacology Network, Systems Pharmacology Community, USA.
CPT Pharmacometrics Syst Pharmacol. 2019 Apr;8(4):205-210. doi: 10.1002/psp4.12390. Epub 2019 Mar 3.
The provision of model code is required for publication in CPT: Pharmacometrics & Systems Pharmacology, enabling quantitative systems pharmacology (QSP) model availability. A searchable repository of published QSP models would enhance model accessibility. We assess the feasibility of establishing such a resource based on 18 QSP models published in this journal. However, because of the diversity of software platforms (nine), file formats, and functionality, such a resource is premature. We evaluated 12 of the models (those coded in R, PK-Sim/MoBi, and MATLAB) for functionality. Of the 12, only 4 were executable in that figures from the associated manuscript could be generated via a "run" script. Many researchers are aware of the challenges involved in repurposing published models. We offer some ideas to enable model sharing going forward, including annotation guidelines, standardized formats, and the inclusion of "run" scripts. If practitioners can agree to some minimum standards for the provision of model code, model reuse and extension would be accelerated.
药代动力学与系统药理学要求提供模型代码，以提供定量系统药理学（QSP）模型。一个可搜索的已发表 QSP 模型存储库将提高模型的可访问性。我们基于本杂志发表的 18 个 QSP 模型评估了建立此类资源的可行性。然而，由于软件平台（9 个）、文件格式和功能的多样性，建立这样的资源还为时过早。我们评估了 12 个模型（用 R、PK-Sim/MoBi 和 MATLAB 编写的模型）的功能。在这 12 个模型中，只有 4 个是可执行的，因为通过“运行”脚本可以生成相关手稿中的图。许多研究人员都意识到重新利用已发表模型所涉及的挑战。我们提供了一些想法，以促进模型共享，包括注释指南、标准化格式和“运行”脚本的纳入。如果从业者能够就模型代码的提供达成一些最低标准，那么模型的重用和扩展将得到加速。
